Novel reversible monoamine oxidase A inhibitors: highly potent and selective 3-(1H-pyrrol-3-yl)-2-oxazolidinones.
type: Dataset
description: Monoamine oxidases (MAOs) are involved in various psychiatric and neurodegenerative disorders; hence, MAO inhibitors are useful agents in the therapy of Parkinson's disease, Alzheimer's dementia, and depression syndrome. Herein we report a novel series of 3-(1H-pyrrol-3-yl)-2-oxazolidinones 3-7 as reversible, highly potent and selective anti-MAO-A agents. In particular, 4b, 5b, and 4c showed a K(i-MAO-A) of 0.6, 0.8, and 1 nM, respectively, 4c being 200000-fold selective for MAO-A with respect to MAO-B.
landing page: 0022-2623
keyword: infoeu-reposemanticsarticle
keyword: journal-articles
keyword: mesh-animals
keyword: mesh-cattle
keyword: mesh-isoenzymes
keyword: mesh-monoamine-oxidase
keyword: mesh-monoamine-oxidase-inhibitors
keyword: mesh-oxazolidinones
keyword: mesh-pyrroles
keyword: mesh-stereoisomerism
keyword: mesh-structure-activity-relationship
keyword: sdvbbmlife-sciences-q-biobiochemistry-molecular-biology
issued: 2026-05-05T14:17:00.265397
modified: 2026-05-05T14:17:00.265402
language: en
contact point: Organization
  fn: CCSD

test_moissonnage_selune
type: Agent

Novel reversible monoamine oxidase A inhibitors: highly potent and selective 3-(1H-pyrrol-3-yl)-2-oxazolidinones.
type: Distribution
format: HTML
access URL: https://riip.hal.science/pasteur-00980200
issued: 2026-05-05T14:17:00.273456
modified: 2026-05-05T14:17:00.249007