@prefix dcat: <http://www.w3.org/ns/dcat#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix foaf: <http://xmlns.com/foaf/0.1/> .
@prefix vcard: <http://www.w3.org/2006/vcard/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

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    dct:description """
              Increased expression or aberrant activation of c-Myc plays an important role in leukemogenesis. Here, we show that in acute myeloid leukemia (AML), c-Myc directly controls the expression of EZH2, a component of the Polycomb repressive complex 2, and miR-26a. miR-26a is downregulated in primary blasts from AML patients and, during myeloid differentiation of AML cells, is induced together with a decrease in c-Myc and Ezh2 levels. Previously, EZH2 was shown to be regulated by miR-26a at the translational levels in lymphomas. However, we demonstrate that in AML, the variation of EZH2 mainly depends on c-Myc transcriptional control. We also show that enforced expression of miR-26a in AML cells is able to inhibit cell cycle progression by downregulating cyclin E2 expression. In addition, increased levels of miR-26a potentiate the antiproliferative effects of 1,25-dihydroxyvitamin D(3) (VitD) and stimulate myeloid differentiation. Our results identify new molecular targets of c-Myc in AML and highlight miR-26a attractiveness as a therapeutic target in leukemia.
            """ ;
    dct:identifier "pasteur-00976767" ;
    dct:issued "2026-05-05T15:29:54.306115"^^xsd:dateTime ;
    dct:language "en" ;
    dct:modified "2026-05-05T15:29:54.306119"^^xsd:dateTime ;
    dct:publisher <https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> ;
    dct:title "Critical Role of c-Myc in Acute Myeloid Leukemia Involving Direct Regulation of miR-26a and Histone Methyltransferase EZH2." ;
    dcat:contactPoint [ a vcard:Organization ;
            vcard:fn "CCSD" ] ;
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    dcat:keyword "infoeu-reposemanticsarticle",
        "journal-articles",
        "sdvbbmlife-sciences-q-biobiochemistry-molecular-biology",
        "sdvcanlife-sciences-q-biocancer" ;
    dcat:landingPage <EISSN:%201947-6027> .

<EISSN:%201947-6027> a foaf:Document .

<https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-pasteur-00976767v1/resource/a8a08b89-71b6-43dc-98a1-3eb05691acb4> a dcat:Distribution ;
    dct:format "HTML" ;
    dct:issued "2026-05-05T15:29:54.310231"^^xsd:dateTime ;
    dct:modified "2026-05-05T15:29:54.299833"^^xsd:dateTime ;
    dct:title "Critical Role of c-Myc in Acute Myeloid Leukemia Involving Direct Regulation of miR-26a and Histone Methyltransferase EZH2." ;
    dcat:accessURL <https://riip.hal.science/pasteur-00976767> .

<https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> a foaf:Agent ;
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