@prefix dcat: <http://www.w3.org/ns/dcat#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix foaf: <http://xmlns.com/foaf/0.1/> .
@prefix vcard: <http://www.w3.org/2006/vcard/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-pasteur-00969585v1> a dcat:Dataset ;
    dct:description """
              New indolylarylsulfone (IAS) derivatives bearing nitrogen containing substituents at the indole-2-carboxamide inhibited the HIV-1 WT in MT-4 cells at low nanomolar concentrations. In particular, compound 9 was uniformly effective against the mutant Y181C, Y188L, and K103N HIV-1 strains; it was highly active against the multidrug resistant mutant IRLL98 HIV-1 strain bearing the K101Q, Y181C, and G190A mutations conferring resistance to NVP, DLV, and EFV and several HIV-1 clades A in PBMC.
            """ ;
    dct:identifier "pasteur-00969585" ;
    dct:issued "2026-05-05T18:47:46.071358"^^xsd:dateTime ;
    dct:language "en" ;
    dct:modified "2026-05-05T18:47:46.071362"^^xsd:dateTime ;
    dct:publisher <https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> ;
    dct:title "New nitrogen containing substituents at the indole-2-carboxamide yield high potent and broad spectrum indolylarylsulfone HIV-1 non-nucleoside reverse transcriptase inhibitors." ;
    dcat:contactPoint [ a vcard:Organization ;
            vcard:fn "CCSD" ] ;
    dcat:distribution <https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-pasteur-00969585v1/resource/697f6a00-9cdf-4a76-8210-01d353a7217d> ;
    dcat:keyword "infoeu-reposemanticsarticle",
        "journal-articles",
        "mesh-cell-line",
        "mesh-hiv-1",
        "mesh-hiv-reverse-transcriptase",
        "mesh-indoles",
        "mesh-mutation",
        "mesh-nitrogen",
        "mesh-reverse-transcriptase-inhibitors",
        "mesh-structure-activity-relationship",
        "mesh-sulfones",
        "sdvsplife-sciences-q-biopharmaceutical-sciences" ;
    dcat:landingPage <ISSN:%200022-2623> .

<ISSN:%200022-2623> a foaf:Document .

<https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-pasteur-00969585v1/resource/697f6a00-9cdf-4a76-8210-01d353a7217d> a dcat:Distribution ;
    dct:format "HTML" ;
    dct:issued "2026-05-05T18:47:46.153430"^^xsd:dateTime ;
    dct:modified "2026-05-05T18:47:46.052857"^^xsd:dateTime ;
    dct:title "New nitrogen containing substituents at the indole-2-carboxamide yield high potent and broad spectrum indolylarylsulfone HIV-1 non-nucleoside reverse transcriptase inhibitors." ;
    dcat:accessURL <https://riip.hal.science/pasteur-00969585> .

<https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> a foaf:Agent ;
    foaf:name "test_moissonnage_selune" .