@prefix dcat: <http://www.w3.org/ns/dcat#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix foaf: <http://xmlns.com/foaf/0.1/> .
@prefix vcard: <http://www.w3.org/2006/vcard/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-pasteur-00859427v1> a dcat:Dataset ;
    dct:description """
              BACKGROUND: Cutaneous leishmaniasis (cl) is a disfiguring disease that confronts clinicians with a quandary: leave patients untreated or engage in a complex or toxic treatment. Topical treatment of CL offers a practical and safe option. Accordingly, the treatment of CL with WR279,396, a formulation of paromomycin and gentamicin in a hydrophilic base, was investigated in a phase 2 clinical study in Tunisia and France. METHODS: A phase 2, randomized, double blind, vehicle-controlled study was conducted to assess the safety and efficacy of topical WR279,396 when applied twice a day for 20 days as treatment for parasitologically confirmed CL. The study protocol established the primary efficacy end point as complete clinical response (CCR) defined as 50% or greater reduction in the ulceration size of an index lesion by day 50 (D50) followed by complete re-epithelialization by D100, and no relapse through D180. RESULTS: Ninety-two subjects were randomized. Leishmania major was identified in 66 of 68 isolates typed (97%). In the intent-to-treat population, 47 of 50 WR279,396 treated participants (94%) met the definition of CCR, compared with 30 of 42 vehicle-placebo participants (71%) [p = 0.0045]. Erythema occurred in 30% and 24% of participants receiving WR279,396 and placebo, respectively [p = 0.64]. There was no clinical or laboratory evidence of systemic toxicity. CONCLUSION: Application of WR279,396 for 20 days was found to be safe and effective in treating L. major CL, and offers great potential as a new, simple, easily applicable, and inexpensive topical therapy for this neglected disease. TRIAL REGISTRATION: ClinicalTrials.gov NCT00703924.
            """ ;
    dct:identifier "pasteur-00859427" ;
    dct:issued "2026-05-09T20:09:39.814039"^^xsd:dateTime ;
    dct:language "en" ;
    dct:modified "2026-05-09T20:09:39.814045"^^xsd:dateTime ;
    dct:publisher <https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> ;
    dct:title "WR279,396, a third generation aminoglycoside ointment for the treatment of Leishmania major cutaneous leishmaniasis: a phase 2, randomized, double blind, placebo controlled study." ;
    dcat:contactPoint [ a vcard:Organization ;
            vcard:fn "CCSD" ] ;
    dcat:distribution <https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-pasteur-00859427v1/resource/bde229e5-d2d9-4a1d-8c65-cf4825978e44> ;
    dcat:keyword "infoeu-reposemanticsarticle",
        "journal-articles",
        "mesh-adolescent",
        "mesh-adult",
        "mesh-aged",
        "mesh-aminoglycosides",
        "mesh-child",
        "mesh-child-preschool",
        "mesh-double-blind-method",
        "mesh-france",
        "mesh-gentamicins",
        "mesh-humans",
        "mesh-leishmania-major",
        "mesh-leishmaniasis-cutaneous",
        "mesh-middle-aged",
        "mesh-ointments",
        "mesh-paromomycin",
        "mesh-placebos",
        "mesh-treatment-outcome",
        "mesh-trypanocidal-agents",
        "mesh-tunisia",
        "mesh-young-adult",
        "sdvlife-sciences-q-bio" ;
    dcat:landingPage <ISSN:%201935-2727> .

<ISSN:%201935-2727> a foaf:Document .

<https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-pasteur-00859427v1/resource/bde229e5-d2d9-4a1d-8c65-cf4825978e44> a dcat:Distribution ;
    dct:format "HTML" ;
    dct:issued "2026-05-09T20:09:39.827104"^^xsd:dateTime ;
    dct:modified "2026-05-09T20:09:39.792668"^^xsd:dateTime ;
    dct:title "WR279,396, a third generation aminoglycoside ointment for the treatment of Leishmania major cutaneous leishmaniasis: a phase 2, randomized, double blind, placebo controlled study." ;
    dcat:accessURL <https://riip.hal.science/pasteur-00859427> .

<https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> a foaf:Agent ;
    foaf:name "test_moissonnage_selune" .