Klebsiella pneumoniae related community-acquired acute lower respiratory infections in Cambodia: clinical characteristics and treatment.
type: Dataset
contact point: Organization
  fn: CCSD
keyword: mesh-anti-bacterial-agents
keyword: mesh-blood
keyword: sdvmpvirlife-sciences-q-biomicrobiology-and-parasitologyvirology
keyword: mesh-risk-factors
keyword: mesh-sputum
keyword: extended-spectrum-betalactamases
keyword: mesh-survival-analysis
keyword: mesh-community-acquired-infections
keyword: community-acquired
keyword: mesh-female
keyword: mesh-humans
keyword: mesh-middle-aged
keyword: mesh-male
keyword: infoeu-reposemanticsarticle
keyword: pneumonia
keyword: mesh-microbial-sensitivity-tests
keyword: mesh-bronchopneumonia
keyword: mesh-aged
keyword: mesh-cambodia
keyword: mesh-klebsiella-pneumoniae
keyword: mesh-klebsiella-infections
keyword: diabetes-mellitus
keyword: klebsiella-pneumoniae
keyword: journal-articles
keyword: mesh-beta-lactamases
keyword: mesh-adult
landing page: 1471-2334
description: BACKGROUND: In many Asian countries, Klebsiella pneumoniae (KP) is the second pathogen responsible for community-acquired pneumonia. Yet, very little is known about KP etiology in ALRI in Cambodia, a country that has one of the weakest medical infrastructures in the region. We present here the first clinico-radiological description of KP community-acquired ALRI in hospitalized Cambodian patients. METHODS: Through ALRI surveillance in two provincial hospitals, KP was isolated from sputum and blood cultures, and identified by API20E gallery from patients ≥ 5 years-old with fever and respiratory symptoms onset ≤14 days. Antibiotics susceptibility testing was provided systematically to clinicians when bacteria were isolated. We collected patients' clinical, radiological and microbiological data and their outcome 3 months after discharge. We also compared KP-related with other bacteria-related ALRI to determine risk factors for KP infection. RESULTS: From April 2007 to December 2009, 2315 ALRI patients ≥ 5 years-old were enrolled including 587 whose bacterial etiology could be assigned. Of these, 47 (8.0%) had KP infection; their median age was 55 years and 68.1% were females. Reported prior medication was high (42.5%). Patients' chest radiographs showed pneumonia (61.3% including 39% that were necrotizing), preexisting parenchyma lesions (29.5%) and pleural effusions alone (4.5%) and normal parenchyma (4.5%). Five patients had severe conditions on admission and one patient died during hospitalization. Of the 39 patients that were hospital discharged, 14 died including 12 within 1 month after discharge. Only 13 patients (28%) received an appropriate antibiotherapy. Extended-spectrum beta-lactamases (ESBL) - producing strains were found in 8 (17.0%) patients. Female gender (Odds ratio (OR) 2.1; p = 0.04) and diabetes mellitus (OR 3.1; p = 0.03) were independent risk factors for KP-related ALRI. CONCLUSIONS: KP ALRI in Cambodia has high fatality rate, are more frequently f…
issued: 2026-05-10T01:22:54.193400
language: en
modified: 2026-05-10T01:22:54.193404

Klebsiella pneumoniae related community-acquired acute lower respiratory infections in Cambodia: clinical characteristics and treatment.
type: Distribution
access URL: https://riip.hal.science/pasteur-00853147
format: HTML
issued: 2026-05-10T01:22:54.195710
modified: 2026-05-10T01:22:54.164160

test_moissonnage_selune
type: Agent