Association of CAT polymorphisms with catalase activity and exposure to environmental oxidative stimuli.
type: Dataset
contact point: Organization
  fn: CCSD
keyword: infoeu-reposemanticsarticle
keyword: mesh-glutathione-peroxidase
keyword: mesh-lymphotoxin
keyword: mesh-coal-mining
keyword: mesh-res
keyword: mesh-oxidation-reduction
keyword: journal-articles
keyword: mesh-adult
keyword: mesh-oxidants
keyword: mesh-research-support-nih-extramural
keyword: mesh-genotype
keyword: mesh-catalase
keyword: mesh-polymorphism-single-nucleotide
keyword: mesh-environmental-pollutants
keyword: mesh-coal
keyword: mesh-dust
keyword: sdvspeelife-sciences-q-biosante-publique-et-epidemiologie
keyword: sdvbbmlife-sciences-q-biobiochemistry-molecular-biology
keyword: mesh-middle-aged
keyword: mesh-humans
keyword: mesh-erythrocytes
landing page: Free Radic Res
description: We tested the hypotheses that catalase activity is modified by CAT single nucleotide polymorphisms (SNPs) (-262;-844), and by their interactions with oxidant exposures (coal dusts, smoking), lymphotoxin alpha (LTA, NcoI) and tumor necrosis factor (TNF, -308) in 196 miners. Erythrocyte catalase, superoxide dismutase, and glutathione peroxidase activities were measured. The CAT -262 SNP was related to lower catalase activity (104, 87 and 72 k/g hemoglobin for CC, CT and TT, respectively, p < 0.0001). Regardless of CAT SNPs, the LTA NcoI but not the TNF-308 SNP was associated with catalase activity (p = 0.04 and p = 0.8). CAT -262 T carriers were less frequent in highly exposed miners (OR = 0.39 [0.20-0.78], p = 0.007). In CAT -262 T carriers only, catalase activity decreased with high dust exposure (p = 0.01). Haplotype analyses (combined CAT SNPs) confirm these results. Results show that CAT -262 and LTA NcoI SNPs, and interaction with coal dust exposure, influenced catalase activity.
issued: 2026-05-10T01:00:35.122122
language: en
modified: 2026-05-10T01:00:35.122127

test_moissonnage_selune
type: Agent

Association of CAT polymorphisms with catalase activity and exposure to environmental oxidative stimuli.
type: Distribution
access URL: https://inserm.hal.science/inserm-00085360
format: HTML
issued: 2026-05-10T01:00:35.124556
modified: 2026-05-10T01:00:35.100752