@prefix dcat: <http://www.w3.org/ns/dcat#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix foaf: <http://xmlns.com/foaf/0.1/> .
@prefix vcard: <http://www.w3.org/2006/vcard/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-inserm-00000115v1> a dcat:Dataset ;
    dct:description """
              BACKGROUND: Sickle cell disease (SCD) affects the kidney by acute mechanisms as well as by insidious renal medullary/papillary necrosis, resulting in tubular defects, which increase the risk of dehydration and subsequent sickle crisis. Hypoxia has been reported to stimulate endothelin-1 (ET-1) synthesis by endothelial cells and also in the renal tubule. METHODS: This case-control study measured ET-1 in urine as a marker of its renal synthesis in asymptomatic SCD patients. Baseline plasma and urinary ET-1 levels were measured and followed during a water deprivation study and a subsequent administration of desmopressin. RESULTS: Urine and plasma levels of ET-1 were elevated in patients with SCD, compared with carefully matched African-French and African controls, and urine ET-1 excretion was associated with a marked urine-concentrating defect. Moreover, urinary ET-1 output was correlated with microalbuminuria in SCD patients. CONCLUSIONS: ET-1 is known to antagonize the tubular effects of vasopressin and to promote renal scarring; increased renal production of ET-1 could produce nephrogenic diabetes insipidus and dehydration in SCD patients through a combination of fibrosis and functional resistance to vasopressin. This study provides a rationale for trials with endothelin receptor antagonists in sickle cell disease nephropathy.
            """ ;
    dct:identifier "inserm-00000115" ;
    dct:issued "2026-05-27T14:59:45.805377"^^xsd:dateTime ;
    dct:language "en" ;
    dct:modified "2026-05-27T14:59:45.805383"^^xsd:dateTime ;
    dct:publisher <https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> ;
    dct:title "Urinary endothelin-1 as a marker of renal damage in sickle cell disease." ;
    dcat:contactPoint [ a vcard:Organization ;
            vcard:fn "CCSD" ] ;
    dcat:distribution <https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-inserm-00000115v1/resource/b5961f76-ddcb-483b-a827-8a425f94a9e4> ;
    dcat:keyword "infoeu-reposemanticsarticle",
        "journal-articles",
        "mesh-adult",
        "mesh-albuminuria",
        "mesh-anemia-sickle-cell",
        "mesh-biological-markers",
        "mesh-case-control-studies",
        "mesh-comparative-study",
        "mesh-diabetes-insipidus-nephrogenic",
        "mesh-disease-progression",
        "mesh-endothelin-1",
        "mesh-female",
        "mesh-humans",
        "mesh-kidney-tubules",
        "mesh-male",
        "mesh-radioimmunoassay",
        "mesh-research-support-non-us-go",
        "sdvmhepunlife-sciences-q-biohuman-health-and-pathologyurology-and-nephrology" ;
    dcat:landingPage <ISSN:%200931-0509> .

<ISSN:%200931-0509> a foaf:Document .

<https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-inserm-00000115v1/resource/b5961f76-ddcb-483b-a827-8a425f94a9e4> a dcat:Distribution ;
    dct:format "HTML" ;
    dct:issued "2026-05-27T14:59:45.932695"^^xsd:dateTime ;
    dct:modified "2026-05-27T14:59:45.752957"^^xsd:dateTime ;
    dct:title "Urinary endothelin-1 as a marker of renal damage in sickle cell disease." ;
    dcat:accessURL <https://inserm.hal.science/inserm-00000115> .

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