@prefix dcat: <http://www.w3.org/ns/dcat#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix foaf: <http://xmlns.com/foaf/0.1/> .
@prefix vcard: <http://www.w3.org/2006/vcard/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-hal-00998117v1> a dcat:Dataset ;
    dct:description """
              Brevetoxin B is a highly reactive molecule, due in part to an α,β-unsaturated aldehyde group at the terminal side chain, leading to metabolism by reduction, oxidation and conjugation. These reactions have little effect to reduce intrinsic activity at the voltage-gated sodium channel or during toxicity testing by either enzyme-linked immunosorbent assay or mouse bioassay. Here we investigate the potential for intestinal absorption of the two most abundant brevetoxins present in Gulf of Mexico oysters using human Caco-2 cell monolayers, a widely utilized in vitro test to predict oral bioavailability of drugs and their metabolites. We found that both dihydrobrevetoxin B and cysteine brevetoxin B were rapidly taken up by the Caco-2 monolayer. However, only dihydrobrevetoxin B passes through the monolayer to reach the basal compartment. Dihydrobrevetoxin B has a moderate apparent permeability coefficient of 1.6×10-6cm/s at 500ng/mL and nearly 50% of the toxin passes from the apical to basal compartment in 24h. The inability of the cysteine brevetoxin B to pass through an intestinal epithelial barrier suggests that this bioactive brevetoxin metabolite that persists in shellfish may not contribute to neurotoxic shellfish poisoning.
            """ ;
    dct:identifier "hal-00998117" ;
    dct:issued "2026-05-05T09:58:06.972494"^^xsd:dateTime ;
    dct:language "en" ;
    dct:modified "2026-05-05T09:58:06.972499"^^xsd:dateTime ;
    dct:publisher <https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> ;
    dct:title "Permeability of dihydro- and cysteine-brevetoxin metabolites across a Caco-2 cell monolayer" ;
    dcat:contactPoint [ a vcard:Organization ;
            vcard:fn "CCSD" ] ;
    dcat:distribution <https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-hal-00998117v1/resource/18cb308c-3e04-4841-b570-b2acf7ce1a09> ;
    dcat:keyword "brevetoxin",
        "brevetoxine",
        "caco-2",
        "infoeu-reposemanticsarticle",
        "journal-articles",
        "marine-toxin",
        "sdvtoxlife-sciences-q-biotoxicology",
        "toxicologie",
        "toxicology",
        "toxin",
        "toxine" ;
    dcat:landingPage <ISSN:%201568-9883> .

<ISSN:%201568-9883> a foaf:Document .

<https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-hal-00998117v1/resource/18cb308c-3e04-4841-b570-b2acf7ce1a09> a dcat:Distribution ;
    dct:format "HTML" ;
    dct:issued "2026-05-05T09:58:06.979414"^^xsd:dateTime ;
    dct:modified "2026-05-05T09:58:06.960855"^^xsd:dateTime ;
    dct:title "Permeability of dihydro- and cysteine-brevetoxin metabolites across a Caco-2 cell monolayer" ;
    dcat:accessURL <https://anses.hal.science/hal-00998117> .

<https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> a foaf:Agent ;
    foaf:name "test_moissonnage_selune" .