@prefix dcat: <http://www.w3.org/ns/dcat#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix foaf: <http://xmlns.com/foaf/0.1/> .
@prefix vcard: <http://www.w3.org/2006/vcard/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-hal-00849247v1> a dcat:Dataset ;
    dct:description """
              Context: Besides their potential action in the treatment of type 2 diabetes mellitus (T2DM), GLP-1 analogues have been shown to decrease satiety and food intake. However, little is known about their effects on food hedonic and taste perceptions. Objective: The objective of the study was to investigate the impact of GLP-1 analogue Liraglutide on the liking and wanting component of the food reward system as well as on taste sensitivity in T2DM patients. Research design and methods: Thirty T2DM patients were studied before and after 3 months of daily Liraglutide treatment (1.2 mg). In each trial, blood samples were collected and body mass composition was analyzed by dual-energy X-ray absorptiometry. Liking, recalled liking and wanting for lipids, proteins and carbohydrates were assessed and detection thresholds for salt, sweet and bitter tastes were measured. Results: After three months of daily treatment with Liraglutide, T2DM patients had a significant decrease in hunger sensation (p<0.01), food intake (p<0.01) and weight (p<0.01) but not in the pleasure in eating. A reduction in plasma leptin (p<0.01) and ghrelin (p<0.01) levels was also observed. Liking (p=0.04), recalled liking (p=0.05) and wanting (p<0.01) for fatty foods were lowered by the treatment. Sensitivity to sweet taste was improved (p=0.04) whereas it remained unchanged for salty and bitter tastes. Conclusions: This is the first study to show a decrease in hedonic response for fatty foods and an increase in sweet taste sensitivity induced by GLP-1 analogues. These results are of interest in the understanding of weight loss mechanisms and cardiovascular risk improvement induced by GLP-1 analogues.
            """ ;
    dct:identifier "hal-00849247" ;
    dct:issued "2026-05-10T04:43:06.691149"^^xsd:dateTime ;
    dct:language "en" ;
    dct:modified "2026-05-10T04:43:06.691154"^^xsd:dateTime ;
    dct:publisher <https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> ;
    dct:title "Treatment by GLP-1 agonist modulates hedonic response to food and taste sensitivity in type 2 diabetes" ;
    dcat:contactPoint [ a vcard:Organization ;
            vcard:fn "CCSD" ] ;
    dcat:distribution <https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-hal-00849247v1/resource/cd467cde-c1e7-49db-a6f0-ef08a85fbd6b> ;
    dcat:keyword "glp-1-analogue",
        "gustation",
        "infoeu-reposemanticsarticle",
        "journal-articles",
        "liking",
        "nutrition",
        "pharmacology--pharmacy",
        "satiety",
        "sdvbbmlife-sciences-q-biobiochemistry-molecular-biology" ;
    dcat:landingPage <ISSN:%200767-3981> .

<ISSN:%200767-3981> a foaf:Document .

<https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-hal-00849247v1/resource/cd467cde-c1e7-49db-a6f0-ef08a85fbd6b> a dcat:Distribution ;
    dct:format "HTML" ;
    dct:issued "2026-05-10T04:43:06.697033"^^xsd:dateTime ;
    dct:modified "2026-05-10T04:43:06.682262"^^xsd:dateTime ;
    dct:title "Treatment by GLP-1 agonist modulates hedonic response to food and taste sensitivity in type 2 diabetes" ;
    dcat:accessURL <https://institut-agro-rennes-angers.hal.science/hal-00849247> .

<https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> a foaf:Agent ;
    foaf:name "test_moissonnage_selune" .