@prefix dcat: <http://www.w3.org/ns/dcat#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix foaf: <http://xmlns.com/foaf/0.1/> .
@prefix vcard: <http://www.w3.org/2006/vcard/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-hal-00841091v1> a dcat:Dataset ;
    dct:description """
              The objective of this study was to provide insight into the biological mechanisms underlying mammary development and the role of the ovaries in prepubertal caprine mammogenesis using a serial ovariectomy approach. Young Alpine goats were ovariectomized (Ovx) or sham-operated (Int) at three periods before puberty (G1=1 month, G2=2 month and G3=3 months of age) and one after puberty (G7=7 months of age). The goats were slaughtered at 9 months of age and mammary glands were removed. Ovariectomy performed at 1, 2 and 3 months of age caused a 50% reduction in DNA concentration, in mammary tissue taken from the parenchyma-stroma border region. Morphological analysis of mammary tissue sections indicated that the parenchymal structures of Ovx goats were negatively affected by ovariectomy. Goats ovariectomized before 2 months of age (Ovx-1 and Ovx-2) showed a significant decrease in the percent of cells proliferating in mammary glands of 9-month old goats (proliferating cell nuclear antigen expression and antigen Ki67-positive cell number). Also, goats ovariectomized at 1 and 2 months of age had reduced matrix metalloprotease 2 activity at 9 months of age. E-cadherin was strongly decreased in goats ovariectomized before 2 months of age (80 and 85% in Ovx-1 and Ovx-2 goats, respectively). Quantitative PCR analysis of transcripts encoding for oestrogen (ERalpha) and progesterone receptors (PR) and immunodetection of ERalpha showed that ovariectomy at 1 and 2 months of age strongly inhibited the transcription of ERalpha and PR in the mammary gland. We conclude that ovariectomy before 3 months of age markedly impaired parenchymal development. These findings suggest that prepubertal mammogenesis in goats depends on the ovaries to initiate mammary epithelial cell proliferation and mammary gland remodelling.
            """ ;
    dct:identifier "hal-00841091" ;
    dct:issued "2026-05-10T11:41:10.723417"^^xsd:dateTime ;
    dct:language "en" ;
    dct:modified "2026-05-10T11:41:10.723421"^^xsd:dateTime ;
    dct:publisher <https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> ;
    dct:title "Suppression of ovarian secretions before puberty strongly affects mammogenesis in the goat" ;
    dcat:contactPoint [ a vcard:Organization ;
            vcard:fn "CCSD" ] ;
    dcat:distribution <https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-hal-00841091v1/resource/aef44e97-ff41-43a4-ae88-ee84c60b8094> ;
    dcat:keyword "agriculture-dairy--animal-science",
        "dairy-goat",
        "infoeu-reposemanticsarticle",
        "journal-articles",
        "mammary-parenchymal-development",
        "ovariectomy",
        "puberty",
        "sdvsaspalife-sciences-q-bioagricultural-sciencesanimal-production-studies" ;
    dcat:landingPage <ISSN:%200022-0299> .

<ISSN:%200022-0299> a foaf:Document .

<https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-hal-00841091v1/resource/aef44e97-ff41-43a4-ae88-ee84c60b8094> a dcat:Distribution ;
    dct:format "HTML" ;
    dct:issued "2026-05-10T11:41:10.725530"^^xsd:dateTime ;
    dct:modified "2026-05-10T11:41:10.713080"^^xsd:dateTime ;
    dct:title "Suppression of ovarian secretions before puberty strongly affects mammogenesis in the goat" ;
    dcat:accessURL <https://institut-agro-rennes-angers.hal.science/hal-00841091> .

<https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> a foaf:Agent ;
    foaf:name "test_moissonnage_selune" .