Imaging of non tumorous and tumorous human brain tissue with full-field optical coherence tomography
type: Dataset
description: A prospective study was performed on neurosurgical samples from 18 patients to evaluate the use of Full-Field Optical Coherence Tomography (FF-OCT) in brain tumor diagnosis. FF-OCT captures en face slices of tissue samples at 1μm resolution in 3D with a typical 200μm imaging depth. A 1cm2 specimen is scanned at a single depth and processed in about 5 minutes. This rapid imaging process is non-invasive and 30 requires neither contrast agent injection nor tissue preparation, which makes it particularly well suited to medical imaging applications. Temporal chronic epileptic parenchyma and brain tumors such as meningiomas, low- grade and high-grade gliomas, and choroid plexus papilloma were imaged. A subpopulation of neurons, myelin fibers and CNS vasculature were clearly identified. Cortex could be discriminated from white matter, but individual glial cells as astrocytes (normal or reactive) or oligodendrocytes were not observable. This study reports for the first time on the feasibility of using FF-OCT in a real-time manner as a label-free non-invasive imaging technique in an intra-operative neurosurgical clinical setting to assess tumorous glial and epileptic margins.
issued: 2026-05-13T02:58:11.377635
language: en
modified: 2026-05-13T02:58:11.377640
contact point: Organization
  fn: CCSD
keyword: brain-imaging
keyword: brain-tumor
keyword: digital-pathology
keyword: glioma
keyword: infoeu-reposemanticspreprint
keyword: infoinfo-btcomputer-science-csbiotechnology
keyword: optical-imaging
keyword: physphysphys-opticsphysics-physicsphysics-physicsoptics-physicsoptics
keyword: preprints-working-papers-
keyword: sdvbiolife-sciences-q-biobiotechnology
keyword: sdvcanlife-sciences-q-biocancer
keyword: sdvibimalife-sciences-q-biobioengineeringimaging
keyword: sdvmhepahalife-sciences-q-biohuman-health-and-pathologytissues-and-organs-q-bioto
keyword: sdvmhepchilife-sciences-q-biohuman-health-and-pathologysurgery
keyword: sdvneunblife-sciences-q-bioneurons-and-cognition-q-bioncneurobiology
keyword: spioptiengineering-sciences-physicsoptics--photonic
landing page: https://hal.science/hal-00799096

Imaging of non tumorous and tumorous human brain tissue with full-field optical coherence tomography
type: Distribution
format: HTML
issued: 2026-05-13T02:58:11.384552
modified: 2026-05-13T02:58:11.341798
access URL: https://hal.science/hal-00799096

test_moissonnage_selune
type: Agent