On the estimation of sequestered parasite population in falciparum malaria patients
type: Dataset
description: The aim of this paper is to give an estimation of total parasite burden of the patient and the rate of infection in a malaria's intra-host model by using control theory tools. More precisely, we use an auxiliary system called observer whose solutions tend exponentially to those of the original model. This observer uses only the available measurable data that are the values of peripheral infected erythrocytes and provides estimates of the sequestered ones that cannot be measured by clinical methods. Therefore this allows to estimate the total parasite burden within a malaria patient. Moreover the constructed observer does not use the generally unknown infection rate parameter $\beta$. We also derive a simple method to estimate this parameter $\beta$. We apply this estimation method using real data that have been collected when malaria was used as therapy for neurosyphilis by the US Public Health Service.
landing page: https://inria.hal.science/hal-00764375
identifier: Report N°: RR-8178
keyword: age-structured-model
keyword: estimation
keyword: infoeu-reposemanticsreport
keyword: intra-host-model
keyword: observers
keyword: plasmodium-falciparum
keyword: reports
keyword: sdvmhepmilife-sciences-q-biohuman-health-and-pathologyinfectious-diseases
keyword: sdvspeelife-sciences-q-biosante-publique-et-epidemiologie
keyword: spiautoengineering-sciences-physicsautomatic
issued: 2026-05-09T15:30:09.280916
modified: 2026-05-09T15:30:09.280920
language: en
contact point: Organization
  fn: CCSD

test_moissonnage_selune
type: Agent

On the estimation of sequestered parasite population in falciparum malaria patients
type: Distribution
format: HTML
access URL: https://inria.hal.science/hal-00764375
issued: 2026-05-09T15:30:09.287614
modified: 2026-05-09T15:30:09.267266