@prefix dcat: <http://www.w3.org/ns/dcat#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix foaf: <http://xmlns.com/foaf/0.1/> .
@prefix vcard: <http://www.w3.org/2006/vcard/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

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    dct:description """
              Proteasomes are responsible for the cytoplasmic turnover of the vast majority of proteins including regulatory proteins. We have synthesized lipopeptides a new class of non-covalent inhibitors of the 20S proteasome and assayed their inhibitory capacities. Their ability to inhibit at micromolar concentrations chymotrypsin-like and post-acid activities depends on peptide length (3 or 6 amino acids), sequence (presence of a positively or negatively charged amino acid), and alkyl chain length (C6–C18). These structural features could be varied to selectively inhibit one or more of the three proteasome activities
            """ ;
    dct:identifier "hal-00097449" ;
    dct:issued "2026-05-05T16:20:19.401503"^^xsd:dateTime ;
    dct:language "en" ;
    dct:modified "2026-05-05T16:20:19.401508"^^xsd:dateTime ;
    dct:publisher <https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> ;
    dct:title "Development of lipopeptides for inhibiting 20S proteasomes" ;
    dcat:contactPoint [ a vcard:Organization ;
            vcard:fn "CCSD" ] ;
    dcat:distribution <https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-hal-00097449v1/resource/5f30a642-c401-47ed-a120-d3f35615eaa5> ;
    dcat:keyword "infoeu-reposemanticsarticle",
        "inhibitors",
        "journal-articles",
        "lipopeptides",
        "proteasome",
        "spigprocengineering-sciences-physicschemical-and-process-engineering" ;
    dcat:landingPage <ISSN:%200960-894X> .

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<https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-hal-00097449v1/resource/5f30a642-c401-47ed-a120-d3f35615eaa5> a dcat:Distribution ;
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    dct:issued "2026-05-05T16:20:19.402745"^^xsd:dateTime ;
    dct:modified "2026-05-05T16:20:19.393252"^^xsd:dateTime ;
    dct:title "Development of lipopeptides for inhibiting 20S proteasomes" ;
    dcat:accessURL <https://hal.science/hal-00097449> .

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