@prefix dcat: <http://www.w3.org/ns/dcat#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix foaf: <http://xmlns.com/foaf/0.1/> .
@prefix vcard: <http://www.w3.org/2006/vcard/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-hal-00092590v1> a dcat:Dataset ;
    dct:description """
              It is largely established that molecules first discovered in the nervous system are also found in the immune system. Neuropilin-1 (NP-1) was initially identified to mediate semaphorin-induced chemorepulsion during brain development and is also involved in peripheral T cell/dendritic cell interactions. Herein, we studied NP-1 during T cell development in the human thymus. NP-1 is expressed in both cortex and medulla of thymic lobules, being found in distinct CD4/CD8-defined thymocyte subsets. NP-1 is also found in thymic epithelial cells (TEC) in situ and in vitro, and is recruited at the site of TEC-thymocyte contact. Moreover, NP-1 was rapidly up-regulated during thymocyte stimulation by T cell receptor (TCR) and IL-7 or after adhesion to TEC. Semaphorin-3A (Sema-3A), a natural ligand of NP-1, is also present in human thymus, both in TEC and thymocytes, being up-regulated in thymocytes after TCR engagement. Functionally, Sema-3A decreases the adhesion capacity of NP-1(+) thymocytes and induces their migration by a repulsive effect. In conclusion, we show here that NP-1/Sema-3A-mediated interactions participate in the control of human thymocyte development.
            """ ;
    dct:identifier "hal-00092590" ;
    dct:issued "2026-05-07T14:16:27.343273"^^xsd:dateTime ;
    dct:language "en" ;
    dct:modified "2026-05-07T14:16:27.343278"^^xsd:dateTime ;
    dct:publisher <https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> ;
    dct:title "Control of human thymocyte migration by Neuropilin-1/Semaphorin-3A mediated interactions." ;
    dcat:contactPoint [ a vcard:Organization ;
            vcard:fn "CCSD" ] ;
    dcat:distribution <https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-hal-00092590v1/resource/14ef9f91-6478-42d4-add0-94f17f7743b6> ;
    dcat:keyword "extracellular-matrix",
        "infoeu-reposemanticsarticle",
        "integrins",
        "journal-articles",
        "mesh-cell-adhesion",
        "mesh-cell-movement",
        "mesh-chemotaxis",
        "mesh-extracellular-matrixmetabolism",
        "mesh-gene-expression-regulation",
        "mesh-humans",
        "mesh-integrinsmetabolism",
        "mesh-interleukin-7metabolism",
        "mesh-ligands",
        "mesh-neuropilin-1metabolism",
        "mesh-protein-binding",
        "mesh-receptors-antigen-t-cellmetabolism",
        "mesh-semaphorin-3ametabolism",
        "mesh-thymus-glandcytology",
        "mesh-thymus-glandmetabolism",
        "mesh-up-regulation",
        "sdvbbmlife-sciences-q-biobiochemistry-molecular-biology",
        "sdvcanlife-sciences-q-biocancer",
        "thymocyte-adhesion-and-migration" ;
    dcat:landingPage <ISSN:%200027-8424> .

<ISSN:%200027-8424> a foaf:Document .

<https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-hal-00092590v1/resource/14ef9f91-6478-42d4-add0-94f17f7743b6> a dcat:Distribution ;
    dct:format "HTML" ;
    dct:issued "2026-05-07T14:16:27.345864"^^xsd:dateTime ;
    dct:modified "2026-05-07T14:16:27.319709"^^xsd:dateTime ;
    dct:title "Control of human thymocyte migration by Neuropilin-1/Semaphorin-3A mediated interactions." ;
    dcat:accessURL <https://hal.science/hal-00092590> .

<https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> a foaf:Agent ;
    foaf:name "test_moissonnage_selune" .