The SLO-1 BK channel of Caenorhabditis elegans is critical for muscle function and is involved in dystrophin-dependent muscle dystrophy
type: Dataset
description: The Caenorhabditis elegans SLO-1 channel belongs to the family of calcium-activated large conductance BK potassium channels. SLO-1 has been shown to be involved in neurotransmitter release and ethanol response. Here, we report that SLO-1 also has a critical role in muscles. Inactivation of the slo-1 gene in muscles leads to phenotypes similar to those caused by mutations of the dystrophin homologue dys-1. Notably, slo-1 mutations result in a progressive muscle degeneration when put into a sensitized genetic background. slo-1 localization was observed by gfp reporter gene in both the M-line and the dense bodies (Z line) of the C.elegans body-wall muscles. Using the inside-out configuration of the patch clamp technique on body-wall muscle cells of acutely dissected wild-type worms, we characterized a Ca2+-activated K+ channel that was identified unambiguously as SLO-1. Since neither the abundance nor the conductance of SLO-1 was changed significantly in dys-1 mutants compared to wild-type animals, it is likely that the inactivation of dys-1 causes a misregulation of SLO-1. All in all, these results indicate that SLO-1 function in C.elegans muscles is related to the dystrophin homologue DYS-1
landing page: 0022-2836
keyword: caenorhabditis-elegans
keyword: dystrophin
keyword: infoeu-reposemanticsarticle
keyword: journal-articles
keyword: large-conductance-calcium-activated-potassium-channels
keyword: muscular-dystrophy
keyword: sdvotlife-sciences-q-bioother-q-bioot
issued: 2026-05-07T22:11:30.982466
modified: 2026-05-07T22:11:30.982470
language: en
contact point: Organization
  fn: CCSD

test_moissonnage_selune
type: Agent

The SLO-1 BK channel of Caenorhabditis elegans is critical for muscle function and is involved in dystrophin-dependent muscle dystrophy
type: Distribution
format: HTML
access URL: https://hal.science/hal-00091522
issued: 2026-05-07T22:11:30.983640
modified: 2026-05-07T22:11:30.973330