@prefix dcat: <http://www.w3.org/ns/dcat#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix foaf: <http://xmlns.com/foaf/0.1/> .
@prefix vcard: <http://www.w3.org/2006/vcard/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

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              As part of our search for new antimalarial drugs, we have screened for inhibitors of Pfnek-1, a protein kinase of Plasmodium falciparum, in south Pacific marine sponges. On the basis of a preliminary screening, the ethanolic crude extract of a new species of Xestospongia collected in Vanuatu was selected for its promising activity. A bioassay-guided fractionation led us to isolate xestoquinone which inhibits Pfnek-1 with an IC(50) around 1 microM. Among a small panel of plasmodial protein kinases, xestoquinone showed modest protein kinase inhibitory activity toward PfPK5 and no activity toward PfPK7 and PfGSK-3. Xestoquinone showed in vitro antiplasmodial activity against a FCB1 P. falciparum strain with an IC(50) of 3 microM and a weak selectivity index (SI 7). Xestoquinone exhibited a weak in vivo activity at 5mg/kg in Plasmodium berghei NK65 infected mice and was toxic at higher doses.
            """ ;
    dct:identifier "hal-00090890" ;
    dct:issued "2026-05-08T02:49:24.793055"^^xsd:dateTime ;
    dct:language "en" ;
    dct:modified "2026-05-08T02:49:24.793059"^^xsd:dateTime ;
    dct:publisher <https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> ;
    dct:title "Antimalarial potential of xestoquinone, a protein kinase inhibitor isolated from a Vanuatu marine sponge Xestospongia sp." ;
    dcat:contactPoint [ a vcard:Organization ;
            vcard:fn "CCSD" ] ;
    dcat:distribution <https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-hal-00090890v1/resource/9e5e8399-c9ea-484b-a2a2-6a82aaa0e177> ;
    dcat:keyword "antimalarial-drug",
        "antiplasmodial-drug",
        "infoeu-reposemanticsarticle",
        "journal-articles",
        "plasmodium",
        "sdvbbmlife-sciences-q-biobiochemistry-molecular-biology",
        "xestoquinone" ;
    dcat:landingPage <ISSN:%200968-0896> .

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<https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-hal-00090890v1/resource/9e5e8399-c9ea-484b-a2a2-6a82aaa0e177> a dcat:Distribution ;
    dct:format "HTML" ;
    dct:issued "2026-05-08T02:49:24.799874"^^xsd:dateTime ;
    dct:modified "2026-05-08T02:49:24.781265"^^xsd:dateTime ;
    dct:title "Antimalarial potential of xestoquinone, a protein kinase inhibitor isolated from a Vanuatu marine sponge Xestospongia sp." ;
    dcat:accessURL <https://hal.science/hal-00090890> .

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