Selective extraction of organophosphorus nerve agent degradation products by molecularly imprinted solid-phase extraction
type: Distribution
access URL: https://hal.science/hal-00090027
format: HTML
issued: 2026-05-08T09:31:48.346377
modified: 2026-05-08T09:31:48.329862

test_moissonnage_selune
type: Agent

Selective extraction of organophosphorus nerve agent degradation products by molecularly imprinted solid-phase extraction
type: Dataset
contact point: Organization
  fn: CCSD
keyword: solid-phase-extraction
keyword: phosphonates
keyword: nerve-agent
keyword: journal-articles
keyword: organophosphorus
keyword: infoeu-reposemanticsarticle
keyword: chimanalchemical-sciencesanalytical-chemistry
keyword: molecularly-imprinted-polymers
keyword: environment
landing page: 0021-9673
description: The analysis of alkyl alkylphosphonic acids, the degradation products of V and G nerve agents as VX, Sarin or Soman, is an important task for the verification of compliance to the Chemical Weapons Convention. The detection of these contaminants at low concentration levels is often difficult in complex matrices due to the amount of interfering substances. Molecularly imprinted solid-phase extraction technique should allow a selective extraction of these compounds from complex samples, and thus make their detection easier. Two molecularly imprinted polymers (MIPs) prepared with methacrylic acid (MAA) as monomer and pinacolyl methylphosphonic acid (PMPA) as template molecule were synthesised and tested. The first polymer, MIP A, was prepared with ethylene glycol dimethacrylate (EGDMA) in dichloromethane. The second polymer, MIP B, was synthesised using trimethylolpropane trimethacrylate (TRIM) in acetonitrile. To evaluate the selectivity provided by these MIPs, the retention of the ethyl methylphosphonic acid (EMPA) target molecule was studied in parallel on a non-imprinted polymer (NIP). While MIP A does not show any difference compared to NIP A, a good selectivity was obtained for MIP B. After the optimisation of the extraction process, 60% of EMPA can be removed from the NIP B without affecting the retention on the MIP B. A recovery of extraction of 93% was then obtained on the MIP B. Its capacity was then measured and corresponds to 97 μg of EMPA per gram of MIP. Finally, the selectivity of MIP B was clearly demonstrated by applying it to the clean-up of a soil extract spiked with EMPA.
issued: 2026-05-08T09:31:48.344981
language: en
modified: 2026-05-08T09:31:48.344986