New cyanine-oligonucleotide conjugates: relationships between chemical structures and properties
type: Dataset
description: Because the influence of the chemical structure of monomethine cyanine-oligo-2-deoxyribonucleotide (ODN) conjugates on their binding and fluorescence properties has remained largely undetermined, we synthesized and studied a wide range of conjugates with various structural patterns. Different cyanine dyes such as thiocyanine, quinocyanine, and thiazole orange isomers were obtained. In the case of unsymmetrical cyanines, the linker was attached to either the quinoline or the benzothiazole nucleus. The influence of the ODN counterpart was evaluated by linking the cyanines to the 5-end or to an internucleotidic phosphate. In the first case, the influence of neighboring nucleic bases was studied, whereas in the second, the stereochemical configuration at the phosphorus atom bearing the cyanine was investigated. We report here on relationships between the structures of the dyes and conjugates and some of their properties, such as the stability and fluorescence changes observed on their hybridization with the target sequence. This study provides useful information towards the design of ODN-cyanine conjugates.
issued: 2026-05-08T19:55:00.423852
language: en
modified: 2026-05-08T19:55:00.423856
contact point: Organization
  fn: CCSD
keyword: cyanines
keyword: dyespigments
keyword: fluorescent-probes
keyword: infoeu-reposemanticsarticle
keyword: journal-articles
keyword: oligonucleotides
landing page: 0947-6539

New cyanine-oligonucleotide conjugates: relationships between chemical structures and properties
type: Distribution
format: HTML
issued: 2026-05-08T19:55:00.425517
modified: 2026-05-08T19:55:00.410916
access URL: https://hal.science/hal-00088873

test_moissonnage_selune
type: Agent