Location and base selectivity on fragmentation of brominated oligodeoxynucleotides
type: Dataset
description: Bromine-modified oligodeoxynucleotides (ODNs) were fragmented in the electrospray source to study the influence of brominated bases on fragmentation. Several 13-mer ODNs containing a brominated pyrimidine base, BrdU (5-bromodeoxyuridine) or BrdC (5-bromodeoxycytidine), were analyzed. Low cone voltage fragmentation yields a loss of the brominated base with a preferential loss for the brominated base closer to the 5-end (2-position > 4-position > 12-position) as well as a preferential loss of BrdU over BrdC. Higher cone voltage produces backbone fragmentation with complementary an-base and wm ions close to the brominated base. On the basis of these observations, we located the brominated base in the sequence for all of the ODNs studied.
landing page: 1076-5174
keyword: base-selectivity
keyword: electrospray
keyword: fragmentation
keyword: in-source-cid
keyword: infoeu-reposemanticsarticle
keyword: journal-articles
keyword: location-selectivity
keyword: oligodeoxynucleotide
issued: 2026-05-08T20:12:58.242991
modified: 2026-05-08T20:12:58.242997
language: en
contact point: Organization
  fn: CCSD

test_moissonnage_selune
type: Agent

Location and base selectivity on fragmentation of brominated oligodeoxynucleotides
type: Distribution
format: HTML
access URL: https://hal.science/hal-00088837
issued: 2026-05-08T20:12:58.245304
modified: 2026-05-08T20:12:58.221543