@prefix dcat: <http://www.w3.org/ns/dcat#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix foaf: <http://xmlns.com/foaf/0.1/> .
@prefix vcard: <http://www.w3.org/2006/vcard/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-hal-00087786v1> a dcat:Dataset ;
    dct:description """
              The mechanisms underlying the swelling of frog red blood cells (RBC), induced by Pacific (P-CTX-1) and Caribbean (C-CTX-1) ciguatoxins (CTXs), were investigated by measuring the length, width and surface of their elliptic shape. P-CTX-1 (0.5 to 5 nM) and C-CTX-1 (1 nM) induced RBC swelling within 60 min. The CTXs-induced RBC swelling was blocked by apamin (1 μM) and by Sr2+ (1 mM). P-CTX-1-induced RBC swelling was prevented and inhibited by H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (27 μM), an inhibitor of soluble guanylate cyclase (sGC), and NOS blockade by NG methyl-l-arginine (l-NMA; 10 μM). Cytochalasin D (cytD, 10 μM) increased RBC surface and mimicked CTX effect but did not prevent the P-CTX-1-induced l-NMA-sensitive extra increase. Calculations revealed that P-CTX-1 and cytD increase RBC total surface envelop and volume. These data strongly suggest that the molecular mechanisms underlying CTXs-induced RBC swelling involve the NO pathway by an activation of the inducible NOS, leading to sGC activation which modulates intracellular cGMP and regulates L-type Ca2+ channels. The resulting increase in intracellular Ca2+ content, in turn, disrupts the actin cytoskeleton, which causes a water influx and triggers a Ca2+-activated K+ current through SK2 isoform channels.
            """ ;
    dct:identifier "hal-00087786" ;
    dct:issued "2026-05-09T05:26:03.888601"^^xsd:dateTime ;
    dct:language "en" ;
    dct:modified "2026-05-09T05:26:03.888606"^^xsd:dateTime ;
    dct:publisher <https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> ;
    dct:title "Mechanisms involved in the swelling of erythrocytes caused by Pacific and Caribbean ciguatoxins" ;
    dcat:contactPoint [ a vcard:Organization ;
            vcard:fn "CCSD" ] ;
    dcat:distribution <https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-hal-00087786v1/resource/4b82c15f-502a-46aa-9bd9-7cc77387cb03> ;
    dcat:keyword "cell-swelling",
        "ciguatoxins",
        "cytochalasin-d",
        "infoeu-reposemanticsarticle",
        "journal-articles",
        "l-type-ca2-channels",
        "nitric-oxide",
        "nitric-oxide-synthase",
        "red-blood-cells",
        "sdvneunblife-sciences-q-bioneurons-and-cognition-q-bioncneurobiology",
        "soluble-guanylate-cyclase" ;
    dcat:landingPage <ISSN:%201079-9796> .

<ISSN:%201079-9796> a foaf:Document .

<https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-hal-00087786v1/resource/4b82c15f-502a-46aa-9bd9-7cc77387cb03> a dcat:Distribution ;
    dct:format "HTML" ;
    dct:issued "2026-05-09T05:26:03.912084"^^xsd:dateTime ;
    dct:modified "2026-05-09T05:26:03.875349"^^xsd:dateTime ;
    dct:title "Mechanisms involved in the swelling of erythrocytes caused by Pacific and Caribbean ciguatoxins" ;
    dcat:accessURL <https://hal.science/hal-00087786> .

<https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> a foaf:Agent ;
    foaf:name "test_moissonnage_selune" .