@prefix dcat: <http://www.w3.org/ns/dcat#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix foaf: <http://xmlns.com/foaf/0.1/> .
@prefix vcard: <http://www.w3.org/2006/vcard/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

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    dct:description """
              The hypothesis that neuropilin-1 (Npn-1) may interact with heparin-binding proteins other than vascular endothelial growth factor has been tested using an optical biosensor-based binding assay. The results show that fibroblast growth factor (FGF) 1, 2, 4, and 7, FGF receptor 1, hepatocyte growth factor/scatter factor (HGF/SF), FGF-binding protein, normal protease sensitive form of prion protein, antithrombin III, and Npn-1 itself are all able to interact with Npn-1 immobilized on the sensor surface. FGF-2, FGF-4, and HGF/SF are also shown to interact with Npn-1 in a solution assay. Moreover, these protein-protein interactions are dependent on the ionic strength of the medium and are inhibited by heparin, and the kinetics of binding of FGF-2, FGF-4 and HGF/SF to Npn-1 are characterized by fast association rate constants (270,000-1,600,000 m(-1) s(-1)). These results suggest that Npn-1 possesses a "heparin" mimetic site that is able to interact at least in part through ionic bonding with the heparin binding site on many of the proteins studied. Npn-1 was also found to potentiate the growth stimulatory activity of FGF-2 on human umbilical vein endothelial cells, indicating that Npn-1 may not just bind but also regulate the activity of heparin-binding proteins.
            """ ;
    dct:identifier "hal-00087200" ;
    dct:issued "2026-05-09T10:00:36.211110"^^xsd:dateTime ;
    dct:language "en" ;
    dct:modified "2026-05-09T10:00:36.211115"^^xsd:dateTime ;
    dct:publisher <https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> ;
    dct:title "Interactions of multiple heparin binding growth factors with neuropilin-1 and potentiation of the activity of fibroblast growth factor-2." ;
    dcat:contactPoint [ a vcard:Organization ;
            vcard:fn "CCSD" ] ;
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    dcat:keyword "infoeu-reposemanticsarticle",
        "journal-articles",
        "mesh-animals",
        "mesh-binding-sites",
        "mesh-biosensing-techniques",
        "mesh-cell-line",
        "mesh-endothelial-cells",
        "mesh-fibroblast-growth-factor-2",
        "mesh-heparin",
        "mesh-hepatocyte-growth-factor",
        "mesh-humans",
        "mesh-models-molecular",
        "mesh-neuropilin-1",
        "mesh-polysaccharides",
        "mesh-protein-isoforms",
        "mesh-protein-structure-tertiary",
        "mesh-receptor-fibroblast-growth-factor-type-1",
        "mesh-receptor-protein-tyrosine-kinases",
        "mesh-receptors-fibroblast-growth-factor",
        "sdvbbmlife-sciences-q-biobiochemistry-molecular-biology" ;
    dcat:landingPage <ISSN:%200021-9258> .

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<https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-hal-00087200v1/resource/8373e26d-a40e-4f8f-ae25-8c86b458b3fa> a dcat:Distribution ;
    dct:format "HTML" ;
    dct:issued "2026-05-09T10:00:36.244119"^^xsd:dateTime ;
    dct:modified "2026-05-09T10:00:36.189854"^^xsd:dateTime ;
    dct:title "Interactions of multiple heparin binding growth factors with neuropilin-1 and potentiation of the activity of fibroblast growth factor-2." ;
    dcat:accessURL <https://hal.science/hal-00087200> .

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