@prefix dcat: <http://www.w3.org/ns/dcat#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix foaf: <http://xmlns.com/foaf/0.1/> .
@prefix vcard: <http://www.w3.org/2006/vcard/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-hal-00087132v1> a dcat:Dataset ;
    dct:description """
              Brassinosteroids (BRs) are steroid hormones that control many aspects of plant growth and development(1,2). BRs bind to the plasma membrane receptor kinase BRI1, and act through a signalling pathway that involves a glycogen synthase kinase-3-like kinase (BIN2) and a serine/threonine phosphatase (BSU1)(3-5). Previous models proposed that BIN2 negatively regulates BR signalling by controlling the stability and subcellular localization of the related transcription factors BES1 and BZR1 by phosphorylation, in a manner reminiscent of the canonical Wnt signalling pathway of metazoans(6-9). Here we present strong evidence for a different mode of regulation of BR signalling. We show that BES1 is localized constitutively to the nucleus, where its activity is modulated by nuclear-localized BIN2 kinase. BIN2-mediated phosphorylation of BES1 inhibits its DNA-binding activity on BR-responsive target promoters and its transcriptional activity through impaired multimerization. Our observations demonstrate that phosphorylation-dependent inhibition of DNA binding and trans-activation is the key primary mechanism of BES1 regulation.
            """ ;
    dct:identifier "hal-00087132" ;
    dct:issued "2026-05-09T10:33:32.734404"^^xsd:dateTime ;
    dct:language "en" ;
    dct:modified "2026-05-09T10:33:32.734409"^^xsd:dateTime ;
    dct:publisher <https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> ;
    dct:title "Downstream nuclear events in brassinosteroid signalling" ;
    dcat:contactPoint [ a vcard:Organization ;
            vcard:fn "CCSD" ] ;
    dcat:distribution <https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-hal-00087132v1/resource/fbe197cd-cbe8-47fd-975a-144ba6d05d42> ;
    dcat:keyword "arabidopsis",
        "beta-catenin",
        "bzr1",
        "gene-expression",
        "growth",
        "infoeu-reposemanticsarticle",
        "journal-articles",
        "kinase",
        "pathway",
        "receptor",
        "transcription-factor",
        "transduction" ;
    dcat:landingPage <ISSN:%200028-0836> .

<ISSN:%200028-0836> a foaf:Document .

<https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-hal-00087132v1/resource/fbe197cd-cbe8-47fd-975a-144ba6d05d42> a dcat:Distribution ;
    dct:format "HTML" ;
    dct:issued "2026-05-09T10:33:32.737901"^^xsd:dateTime ;
    dct:modified "2026-05-09T10:33:32.720993"^^xsd:dateTime ;
    dct:title "Downstream nuclear events in brassinosteroid signalling" ;
    dcat:accessURL <https://hal.science/hal-00087132> .

<https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> a foaf:Agent ;
    foaf:name "test_moissonnage_selune" .