Up date on IGFBP-4: regulation of IGFBP-4 levels and functions, in vitro and in vivo.
type: Dataset
description: Of the six known high affinity insulin-like growth factor binding-proteins (IGFBPs), IGFBP-4 appears to be unique in that it is the only IGFBP that functions mostly like a traditional binding protein. In this regard, none of the IGF independent effects that have been ascribed for other IGFBPs have been described for IGFBP-4. However, recent in vitro and in vivo studies, in particular the recent identification of pregnancy-associated plasma protein-A as a major IGFBP-4 protease, are consistent with the idea that IGFBP-4 is an extremely important component of IGF system in several tissues including gonads and bone. In this review, we have provided an update on IGFBP-4 research and we have summarized our current understanding of the regulation of levels and actions of IGFBP-4 and proteolytic fragments both in vitro and in vivo.
issued: 2026-05-09T16:49:42.348893
language: en
modified: 2026-05-09T16:49:42.348897
contact point: Organization
  fn: CCSD
keyword: expression
keyword: igfbp-4
keyword: infocomputer-science-cs
keyword: infoeu-reposemanticsarticle
keyword: journal-articles
keyword: papp-a
keyword: proteolysis
keyword: proteolytic-fragments
keyword: sdvlife-sciences-q-bio
landing page: official journal of the Growth Hormone Research Society and the International IGF Research Society.

Up date on IGFBP-4: regulation of IGFBP-4 levels and functions, in vitro and in vivo.
type: Distribution
format: HTML
issued: 2026-05-09T16:49:42.354466
modified: 2026-05-09T16:49:42.339667
access URL: https://hal.science/hal-00086349

test_moissonnage_selune
type: Agent