@prefix dcat: <http://www.w3.org/ns/dcat#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix foaf: <http://xmlns.com/foaf/0.1/> .
@prefix vcard: <http://www.w3.org/2006/vcard/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-hal-00086009v1> a dcat:Dataset ;
    dct:description """
              In vertebrates, most glycinergic inhibitory neurons discharge phasically at a relatively low frequency. Such a pattern of glycine liberation from presynaptic terminals may affect the kinetics of post-synaptic glycine receptors. To examine this influence, we have analyzed the behavior of glycine receptors in response to repetitive stimulation at frequencies at which consecutive outside-out currents did not superimpose (0.5-4 Hz). Neurotransmitter release was mimicked on outside-out patches from zebrafish hindbrain Mauthner cells using fast flow application techniques. The amplitude of outside-out currents evoked by short (1 ms) repetitive applications of a saturating concentration (3 mM) of glycine remained unchanged for application frequencies1 Hz. Glycine-evoked current simulations using a simple Markov model describing zebrafish glycine receptor kinetic behavior, indicates that this down-regulation of glycine receptor efficacy is due to a progressive accumulation of the receptors in a long lasting desensitization state. Our simulations suggest that this down-regulation can occur even when spontaneous inhibitory currents were generated randomly at a frequency>1 Hz.
            """ ;
    dct:identifier "hal-00086009" ;
    dct:issued "2026-05-09T19:36:19.492894"^^xsd:dateTime ;
    dct:language "en" ;
    dct:modified "2026-05-09T19:36:19.492898"^^xsd:dateTime ;
    dct:publisher <https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> ;
    dct:title "Frequency-dependent modulation of glycine receptor activation recorded from the zebrafish larvae hindbrain" ;
    dcat:contactPoint [ a vcard:Organization ;
            vcard:fn "CCSD" ] ;
    dcat:distribution <https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-hal-00086009v1/resource/d836d322-ec46-43b8-9d47-bc96edd0de87> ;
    dcat:keyword "desensitization",
        "frequency",
        "glycine-receptors",
        "infoeu-reposemanticsarticle",
        "journal-articles",
        "modulation",
        "patch-clamp",
        "sdvneusclife-sciences-q-bioneurons-and-cognition-q-bionccognitive-sciences",
        "synaptic-activity" ;
    dcat:landingPage <ISSN:%200306-4522> .

<ISSN:%200306-4522> a foaf:Document .

<https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-hal-00086009v1/resource/d836d322-ec46-43b8-9d47-bc96edd0de87> a dcat:Distribution ;
    dct:format "HTML" ;
    dct:issued "2026-05-09T19:36:19.498624"^^xsd:dateTime ;
    dct:modified "2026-05-09T19:36:19.482830"^^xsd:dateTime ;
    dct:title "Frequency-dependent modulation of glycine receptor activation recorded from the zebrafish larvae hindbrain" ;
    dcat:accessURL <https://hal.science/hal-00086009> .

<https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> a foaf:Agent ;
    foaf:name "test_moissonnage_selune" .