Histopathological alterations and functional brain deficits after transcient hypoxia in the newborn rat pup : a long term follow-up study.
type: Dataset
description: To assess temporal brain deficits consecutive to severe birth hypoxia, newborn rats were exposed for 20 min to 100% N2. This treatment induced a long-term growth retardation and a delayed, but only transient, neuronal loss (approximately 25%) in the CA1 hippocampus and parietal cortex, starting from 3 days and peaking at 6 days post-hypoxia. The expression profiles of various apoptosis-regulating proteins (including Bcl-2, Bax, p53 and caspase-3) were well correlated to the alterations of nuclear morphology depicted by 4,6-diamidino-2-phenylindole (DAPI). Whereas they confirmed a gradual histological recovery, specific DNA fragmentation patterns suggested that birth hypoxia may transiently reactivate the developmental programme of neuronal elimination. Although they successfully achieved various behavioral tests such as the righting reflex, negative geotaxis, locomotor coordination, and the eight-arm maze tasks, both developing and adult hypoxic rats were repeatedly slower than controls, suggesting that birth hypoxia is associated to moderate but persistent impairments of functional capacities.
issued: 2026-05-12T22:55:57.972101
language: en
modified: 2026-05-12T22:55:57.972106
contact point: Organization
  fn: CCSD
keyword: birth-hypoxia
keyword: brain-damage
keyword: brain-repair
keyword: cerebral-cortex
keyword: hippocampus
keyword: infoeu-reposemanticsarticle
keyword: journal-articles
keyword: neurobehavioral-development
keyword: neuronal-apoptosis
keyword: rat-neonate
keyword: sdvbddeolife-sciences-q-biodevelopment-biologyembryology-and-organogenesis
keyword: sdvneusclife-sciences-q-bioneurons-and-cognition-q-bionccognitive-sciences
landing page: 0969-9961

Histopathological alterations and functional brain deficits after transcient hypoxia in the newborn rat pup : a long term follow-up study.
type: Distribution
format: HTML
issued: 2026-05-12T22:55:58.077832
modified: 2026-05-12T22:55:57.936865
access URL: https://hal.science/hal-00079976

test_moissonnage_selune
type: Agent