Motor coordination in mice with hotfoot, Lurcher, and double mutations of the Grid2 gene encoding the delta-2 excitatory amino acid receptor.
type: Dataset
contact point: Organization
  fn: CCSD
keyword: journal-articles
keyword: grid2-gene
keyword: infoeu-reposemanticsarticle
keyword: sdvneusclife-sciences-q-bioneurons-and-cognition-q-bionccognitive-sciences
keyword: mutation
keyword: motor-coordination
landing page: 0031-9384
description: Grid2(ho/ho) is a loss of function gene mutation resulting in abnormal dendritic arborizations of Purkinje cells. These mutants were compared in a series of motor coordination tests requiring balance and equilibrium to nonataxic controls (Grid2(ho/+)) and to a double mutant (Grid2(ho/Lc)) with an inserted Lc mutation. The performance of Grid2(ho/ho) mutant mice was poorer than that of controls on stationary beam, coat hanger, unsteady platform, and rotorod tests. Grid2(ho/Lc) did not differ from Grid2(Lc/+) mice. However, the insertion of the Lc mutation in Grid2(ho/Lc) potentiated the deficits found in Grid2(ho/ho) in stationary beam, unsteady platform, and rotorod tests. These results indicate a deleterious effect of the Lc mutation on Grid2-deficient mice.
issued: 2026-05-14T07:15:27.559414
language: en
modified: 2026-05-14T07:15:27.559421

test_moissonnage_selune
type: Agent

Motor coordination in mice with hotfoot, Lurcher, and double mutations of the Grid2 gene encoding the delta-2 excitatory amino acid receptor.
type: Distribution
access URL: https://hal.science/hal-00079176
format: HTML
issued: 2026-05-14T07:15:27.564061
modified: 2026-05-14T07:15:27.537393