@prefix dcat: <http://www.w3.org/ns/dcat#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix foaf: <http://xmlns.com/foaf/0.1/> .
@prefix vcard: <http://www.w3.org/2006/vcard/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

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    dct:description """
              Neuronal apoptosis plays an essential role in early brain development and contributes to secondary neuronal loss after acute ischaemia. Recent studies have provided evidence that caspase-3 is an important downstream event after hypoxia-ischaemia in the immature brain, but a minor event in the adult brain. Our investigations have focused on cell populations that expressed apoptotic effectors in the enzymatic death pathway including cytochrome c, caspase-9 and caspase-3. Expression, activation and cellular localization of these proteins were studied using cleavage of fluorogenic substrate and immunohistochemistry in neonatal rat brain after unilateral focal ischaemia. Caspase-3 enzyme activity was elevated in brain homogenate between 6 and 48 h after reperfusion. This activation was preceded by that of caspase-9, between 3 and 24 h. Apoptotic cell death was finally accomplished by poly-ADP-ribose polymerase cleavage, an endogenous caspase-3 substrate. In addition, immunodetection demonstrated that cytochrome c and activated caspase-9 and caspase-3 were expressed not only in the neurones, the primarily affected cells, but also within the astrocytes, which constituted a dense network delineating the infarct. These results suggested that glial injury may promote the formation of cystic lesions such as those observed clinically in the newborn brain.
            """ ;
    dct:identifier "hal-00078502" ;
    dct:issued "2026-05-14T16:39:27.326885"^^xsd:dateTime ;
    dct:language "en" ;
    dct:modified "2026-05-14T16:39:27.326890"^^xsd:dateTime ;
    dct:publisher <https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> ;
    dct:title "Apoptotic mitochondrial pathway in neuron and astrocyte after neonatal hypoxia-ischemia in the rat brain." ;
    dcat:contactPoint [ a vcard:Organization ;
            vcard:fn "CCSD" ] ;
    dcat:distribution <https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-hal-00078502v1/resource/12d20395-c3c7-4e59-85d7-1726bae1cf8f> ;
    dcat:keyword "caspase",
        "cell-death",
        "cytochrome-c",
        "infoeu-reposemanticsarticle",
        "journal-articles",
        "rat-pup",
        "sdvneusclife-sciences-q-bioneurons-and-cognition-q-bionccognitive-sciences" ;
    dcat:landingPage <Neuropathol.%20and%20Applied%20Neurobiol.> .

<Neuropathol.%20and%20Applied%20Neurobiol.> a foaf:Document .

<https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-hal-00078502v1/resource/12d20395-c3c7-4e59-85d7-1726bae1cf8f> a dcat:Distribution ;
    dct:format "HTML" ;
    dct:issued "2026-05-14T16:39:27.349289"^^xsd:dateTime ;
    dct:modified "2026-05-14T16:39:27.311189"^^xsd:dateTime ;
    dct:title "Apoptotic mitochondrial pathway in neuron and astrocyte after neonatal hypoxia-ischemia in the rat brain." ;
    dcat:accessURL <https://hal.science/hal-00078502> .

<https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> a foaf:Agent ;
    foaf:name "test_moissonnage_selune" .