@prefix dcat: <http://www.w3.org/ns/dcat#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix foaf: <http://xmlns.com/foaf/0.1/> .
@prefix vcard: <http://www.w3.org/2006/vcard/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-hal-00078419v1> a dcat:Dataset ;
    dct:description """
              The staggerer (sg/sg) mutation is a spontaneous deletion in the Rora gene that prevents the translation of the ligand-binding domain (LBD), leading to the loss of RORα activity. The homozygous Rorasg/sg mutant mouse, whose most obvious phenotype is ataxia associated with cerebellar degeneration, also displays a variety of other phenotypes. The heterozygous Rora+/sg is able to develop a cerebellum which is qualitatively normal but with advancing age suffers a significant loss of cerebellar neuronal cells. A truncated protein synthesized by the mutated allele may play a role, both in Rorasg/sg and Rora+/sg. To determine the effects during life span of true haplo-insufficiency of the RORα protein, derived from the invalidation of the gene, we compared the evolution of Purkinje cell numbers in heterozygous Rora knock-out males (Rora+/-) and in their wildtype counterparts from 1 to 24 months of age. We also compared the evolution of Purkinje cell numbers in Rora+/- and Rora+/sg males from 1 to 9 months. The main finding is that in Rora+/- mice, when only a half dose of protein is synthesized, the deficit was already established at 1 month and did not change during life span. Thus, the effects of aging on PC number were apparent much earlier in Rora+/- than in Rora+/sg, although at 24 months of age the deficit was similar.
            """ ;
    dct:identifier "hal-00078419" ;
    dct:issued "2026-05-14T17:49:30.816539"^^xsd:dateTime ;
    dct:language "en" ;
    dct:modified "2026-05-14T17:49:30.816544"^^xsd:dateTime ;
    dct:publisher <https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> ;
    dct:title "CEREBELLAR PURKINJE CELL LOSS IN HETEROZYGOUS RORA+/-MICE: A LONGITUDINAL STUDY" ;
    dcat:contactPoint [ a vcard:Organization ;
            vcard:fn "CCSD" ] ;
    dcat:distribution <https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-hal-00078419v1/resource/3acbd1e9-7a13-488e-8549-896fed3fb7a0> ;
    dcat:keyword "acm",
        "aging",
        "cerebellum",
        "infoeu-reposemanticsarticle",
        "journal-articles",
        "mutant-mice",
        "neuronal-death",
        "sdvneulife-sciences-q-bioneurons-and-cognition-q-bionc" ;
    dcat:landingPage <ISSN:%200167-7063> .

<ISSN:%200167-7063> a foaf:Document .

<https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-hal-00078419v1/resource/3acbd1e9-7a13-488e-8549-896fed3fb7a0> a dcat:Distribution ;
    dct:format "HTML" ;
    dct:issued "2026-05-14T17:49:30.840322"^^xsd:dateTime ;
    dct:modified "2026-05-14T17:49:30.794981"^^xsd:dateTime ;
    dct:title "CEREBELLAR PURKINJE CELL LOSS IN HETEROZYGOUS RORA+/-MICE: A LONGITUDINAL STUDY" ;
    dcat:accessURL <https://hal.science/hal-00078419> .

<https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> a foaf:Agent ;
    foaf:name "test_moissonnage_selune" .