@prefix dcat: <http://www.w3.org/ns/dcat#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix foaf: <http://xmlns.com/foaf/0.1/> .
@prefix vcard: <http://www.w3.org/2006/vcard/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-hal-00077691v1> a dcat:Dataset ;
    dct:description """
              Caspase-3 has been identified as a key protease in the execution of apoptosis and appears to be an important downstream event after hypoxia-ischemia in the immature brain. The efficacy of a pan-caspase inhibitor, boc-aspartyl-(Ome)-fluoromethyl-ketone (BAF), was tested in a model of unilateral focal ischemia with reperfusion in 7-day-old rats. The BAF inhibitor was given intraperitoneally 5 minutes before reperfusion via the carotid artery. This procedure reduced the activity of caspase-3 by 79% but did not induce a significant reduction in infarct volume (23.8 7.5% versus 30.1 6.4%). Animals were distributed in two populations. One population exhibited an infarct, whereas the other appeared to be fully protected. BAF-treated animals exhibiting an infarct mostly displayed necrotic cell death, whereas apoptotic nuclei were observed in untreated or vehicle-treated animals. Repeated dose of BAF (5 minutes before and 9 hours after reperfusion) did not also provide benefit after neonatal ischemia, although a general trend to reduce lesion was observed (20.5 3.7% versus 34.4 5.9%). These findings raise critical questions about the use of peptide ketone apoptotic inhibitors in improving histopathologic outcomes after neonatal stroke.
            """ ;
    dct:identifier "hal-00077691" ;
    dct:issued "2026-05-15T06:06:55.855866"^^xsd:dateTime ;
    dct:language "en" ;
    dct:modified "2026-05-15T06:06:55.855872"^^xsd:dateTime ;
    dct:publisher <https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> ;
    dct:title "Caspase inhibition after neonatal ischemia in the rat brain." ;
    dcat:contactPoint [ a vcard:Organization ;
            vcard:fn "CCSD" ] ;
    dcat:distribution <https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-hal-00077691v1/resource/75b276e4-98d7-4f22-a5c8-0d6a31962782> ;
    dcat:keyword "apoptosis",
        "caspase",
        "cell-death",
        "infoeu-reposemanticsarticle",
        "journal-articles",
        "necrosis",
        "neonatal-ischemia",
        "sdvneusclife-sciences-q-bioneurons-and-cognition-q-bionccognitive-sciences" ;
    dcat:landingPage <ISSN:%200271-678X> .

<ISSN:%200271-678X> a foaf:Document .

<https://rec.harvest-normandie.data4citizen.com/dataset/oai-hal-hal-00077691v1/resource/75b276e4-98d7-4f22-a5c8-0d6a31962782> a dcat:Distribution ;
    dct:format "HTML" ;
    dct:issued "2026-05-15T06:06:55.859288"^^xsd:dateTime ;
    dct:modified "2026-05-15T06:06:55.836812"^^xsd:dateTime ;
    dct:title "Caspase inhibition after neonatal ischemia in the rat brain." ;
    dcat:accessURL <https://hal.science/hal-00077691> .

<https://rec.harvest-normandie.data4citizen.com/organization/cce9db95-46d9-4dc2-84b6-764215d0a002> a foaf:Agent ;
    foaf:name "test_moissonnage_selune" .