Spatial Memory of Heterozygous Staggerer (Rora(+)/Rora(sg)) Versus Normal (Rora(+)/Rora(+)) Mice During Aging.
type: Dataset
description: Heterozygous staggerer mice (Rora+/Rorasg) and control mice (Rora+/Rora+) of the same C57BL/6J strain background were tested in a spontaneous alternation task at 3 to 24 months old. The results demonstrated a decrement in long-term working memory as early as 6 months in Rora+/Rora+ mice and at 3 months in Rora+/Rorasg mice. Previous studies showed that in both cases, neuronal number in the cerebellar cortex was normal (Doulazmi et al. [1999]). This suggests that age-dependent decrease in long-term working memory would be due to fine structural or biochemical changes preceding neuronal death in the cerebellum. Such subtle changes would occur more precociously in Rora+/Rorasg than in Rora+/Rora+ mice. Also, short-term working memory was preserved in Rora+/Rora+ mice as old as 24 months, but was impaired in 6-month-old Rora+/Rorasg mice.
landing page: Behav Genet.
keyword: aging
keyword: cerebellum
keyword: infoeu-reposemanticsarticle
keyword: journal-articles
keyword: sdvneusclife-sciences-q-bioneurons-and-cognition-q-bionccognitive-sciences
keyword: spatial-memory
keyword: spontaneous-alternation
keyword: staggerer-mutant-mouse
issued: 2026-05-15T06:43:39.732988
modified: 2026-05-15T06:43:39.732993
language: en
contact point: Organization
  fn: CCSD

test_moissonnage_selune
type: Agent

Spatial Memory of Heterozygous Staggerer (Rora(+)/Rora(sg)) Versus Normal (Rora(+)/Rora(+)) Mice During Aging.
type: Distribution
format: HTML
access URL: https://hal.science/hal-00077644
issued: 2026-05-15T06:43:39.769701
modified: 2026-05-15T06:43:39.714890