Food restriction affects energy metabolism in rat liver mitochondria
type: Dataset
description: To examine the effect of 50% food restriction over a period of 3 days on mitochondrial energy metabolism, liver mitochondria were isolated from ad libitum and food-restricted rats. Mitochondrial enzyme activities and oxygen consumption were assessed spectrophotometrically and polarographically. With regard to body weight loss (-5%), food restriction decreased the liver to body mass ratio by 7%. Moreover, in food-restricted rats, liver mitochondria displayed diminished state 3 (-30%), state 4-oligomycin (-26%) and uncoupled state (-24%) respiration rates in the presence of succinate. Furthermore, "top-down" elasticity showed that these decreases were due to an inactivation of reactions involved in substrate oxidation. Therefore, it appears that rats not only adapt to food restriction through simple passive mechanisms, such as liver mass loss, but also through decreased mitochondrial energetic metabolism.
landing page: 0006-3002
keyword: calorie-restriction
keyword: energy-metabolism
keyword: infoeu-reposemanticsarticle
keyword: journal-articles
keyword: mitochondrion
keyword: oxidative-phosphorylation
keyword: respiratory-chain-complex
keyword: sdvotlife-sciences-q-bioother-q-bioot
issued: 2026-05-19T11:31:21.813460
modified: 2026-05-19T11:31:21.813466
language: en
contact point: Organization
  fn: CCSD

test_moissonnage_selune
type: Agent

Food restriction affects energy metabolism in rat liver mitochondria
type: Distribution
format: HTML
access URL: https://hal.science/hal-00069597
issued: 2026-05-19T11:31:21.878268
modified: 2026-05-19T11:31:21.792845