Influence of host-recipient origin on clinical aspects of posttransplantation lymphoproliferative disorders in kidney transplantation.
type: Dataset
description: BACKGROUND: Posttransplantation lymphoproliferative disorder (PTLD) is a well-known complication of immunosuppression associated with solid organ transplantation. The donor or host origin of PTLD may influence the outcome of the disease as it has been reported that a donor origin may be associated with a better prognosis. The aim of the study was to determine the origin (recipient or donor) of 12 PTLD occurring in kidney transplant recipients and to correlate the results with clinical findings. METHODS: Origin of PTLD was determined using HLA DRB1 molecular typing, analysis of multiple short-tandem repeat microsatellite loci, and HLA class I antigen expression by immunohistochemistry. RESULTS: Combining the three techniques, we found that eight cases originated from the recipient and four cases originated from the donor. The results of the three techniques were concordant and altogether assigned the origin of the tumors. All the donor-origin PTLD were strictly localized to the kidney graft, developed after a mean time of 5 months after transplantation, and regressed after reduction of immunosuppression. In contrast, seven of the eight recipient-origin PTLD presented as multisystemic disease, occurred a mean time of 75.7 months after the transplantation, and had a worse outcome (mortality, five deaths of eight patients, 62.5%). CONCLUSIONS: These results suggest that PTLD originating from the donor arise in the first year after transplantation into the graft, and that recipient-origin PTLD develop later as an invasive disease. Because it permits simultaneously the analysis of cell morphology and tumor origin, immunohistochemistry is a more reliable technique in the case of graft tumors associated with allograft rejection. The determination of the origin of the tumors seems to be of value in the management of PTLD to predict the outcome and to adapt therapy.
issued: 2026-05-27T05:42:20.341382
language: en
modified: 2026-05-27T05:42:20.341389
contact point: Organization
  fn: CCSD
keyword: infoeu-reposemanticsarticle
keyword: journal-articles
keyword: mesh-adult
keyword: mesh-aged
keyword: mesh-dna
keyword: mesh-female
keyword: mesh-genes-mhc-class-i
keyword: mesh-histocompatibility-testing
keyword: mesh-hla-dr-antigens
keyword: mesh-humans
keyword: mesh-immunohistochemistry
keyword: mesh-isoantibodies
keyword: mesh-kidney-transplantation
keyword: mesh-lymphoproliferative-disorders
keyword: mesh-male
keyword: mesh-middle-aged
keyword: nlm
keyword: sdvimmlife-sciences-q-bioimmunology
landing page: 0041-1337

Influence of host-recipient origin on clinical aspects of posttransplantation lymphoproliferative disorders in kidney transplantation.
type: Distribution
format: HTML
issued: 2026-05-27T05:42:20.493074
modified: 2026-05-27T05:42:20.288848
access URL: https://hal.science/hal-00023697

test_moissonnage_selune
type: Agent