Analysis of three genetic markers in IgA nephropathy patients from a single region.
type: Dataset
description: BACKGROUND: IgA nephropathy (IgA-N) is the most common glomerular disease. Various genetic factors have been suspected to influence the disease, but they never have been studied in the same cohort of patients. METHODS: In 125 IgA-N biopsy-proven cases, we studied by DNA techniques the allele distribution of 3 polymorphic loci: the angiotensin-converting enzyme (ACE) gene, the specific HLA-DQB1 gene and the hs1,2 enhancer of the alpha1 gene of the IgH locus. Patients were classified as progressive and non-progressive based on a creatininemia above 150 microl/ml or/and a deterioration of the clearance greater than 3 ml/min/year. We analyzed the influence of the polymorphism on the development and the progression of the disease. The control group consisted of 83 heathly subjects. RESULTS: The frequency of HLA-DQB1*0602 was decreased in IgA-N patients (3.6% vs 10.2%, Pc = 0.04, RR = 0.36), suggesting a protective effect of this allele for IgA-N. Kaplan-Meyer analysis with the Cox-proportional hazard model revealed a shorter time between diagnosis and renal failure in patients with the B allele for the al gene hs1,2 enhancer (p = 0.04). ACE polymorphism did not influence the development or the progression of the disease. CONCLUSION: Genes controlling the immune response, such as HLA DQB1 and the alpha1 transcriptional enhancer gene, may influence the development and/or the progression of IgA-N nephropathy. Patients who develop an IgA-N nephropathy have a higher risk of severe evolution if they have a profile of high IgA humoral responder.
landing page: 0301-0430
keyword: infoeu-reposemanticsarticle
keyword: journal-articles
keyword: mesh-adolescent
keyword: mesh-adult
keyword: mesh-aged
keyword: mesh-alleles
keyword: mesh-disease-progression
keyword: mesh-female
keyword: mesh-follow-up-studies
keyword: mesh-france
keyword: mesh-gene-frequency
keyword: mesh-genetic-markers
keyword: mesh-genetic-predisposition-to-disease
keyword: mesh-genotype
keyword: mesh-glomerulonephritis-iga
keyword: mesh-humans
keyword: mesh-male
keyword: mesh-middle-aged
keyword: mesh-polymorphism-genetic
keyword: mesh-proportional-hazards-models
keyword: nlm
keyword: sdvimmlife-sciences-q-bioimmunology
issued: 2026-05-28T15:12:16.180982
modified: 2026-05-28T15:12:16.180988
language: en
contact point: Organization
  fn: CCSD

test_moissonnage_selune
type: Agent

Analysis of three genetic markers in IgA nephropathy patients from a single region.
type: Distribution
format: HTML
access URL: https://hal.science/hal-00023535
issued: 2026-05-28T15:12:16.431488
modified: 2026-05-28T15:12:16.040242