Epigenetics in C. elegans: Facts and challenges
type: Dataset
contact point: Organization
  fn: CCSD
keyword: chromatin
keyword: trithorax
keyword: core-histones
keyword: hox
keyword: pcg
keyword: sdvbbmlife-sciences-q-biobiochemistry-molecular-biology
keyword: journal-articles
keyword: infoeu-reposemanticsarticle
keyword: post-translational-modifications
landing page: 1526-954X
description: Epigenetics is defined as the study of heritable changes in gene expression that are not accompanied by changes in the DNA sequence. Epigenetic mechanisms include histone post-translational modifications, histone variant incorporation, non-coding RNAs, and nucleosome remodeling and exchange. In addition, the functional compartmentalization of the nucleus also contributes to epigenetic regulation of gene expression. Studies on the molecular mechanisms underlying epigenetic phenomena and their biological function have relied on various model systems, including yeast, plants, flies, and cultured mammalian cells. Here we will expose the reader to the current understanding of epigenetic regulation in the roundworm C. elegans. We will review recent models of nuclear organization and its impact on gene expression, the biological role of enzymes modifying core histones, and the function of chromatin-associated factors, with special emphasis on Polycomb (PcG) and Trithorax (Trx-G) group proteins. We will discuss how the C. elegans model has provided novel insight into mechanisms of epigenetic regulation as well as suggest directions for future research.
issued: 2026-05-11T10:42:06.341059
language: en
modified: 2026-05-11T10:42:06.341065

test_moissonnage_selune
type: Agent

Epigenetics in C. elegans: Facts and challenges
type: Distribution
access URL: https://ens-lyon.hal.science/ensl-00814756
format: HTML
issued: 2026-05-11T10:42:06.358467
modified: 2026-05-11T10:42:06.323478