Two-color in vivo imaging of photoreceptor apoptosis and development in Drosophila
type: Dataset
description: We report a new two-color fluorescent imaging system to visualize the mosaic adult photoreceptor neurons (PRs) in real-time. Using this method, we examined a collection of 434 mutants and identified genes required for PR survival, planar cell polarity (PCP), patterning and differentiation. We could track the progression of PR degeneration in living flies. By introducing the expression of p35, a caspase inhibitor, we found mutations that specifically activate caspase-dependent death. Moreover, we showed that grh is required in R3 for correct PCP establishment. The "Tomato/GFP-FLP/FRT" method allows high-throughput, rapid and precise identification of survival and developmental pathways in living adult PRs at single-cell resolut
landing page: 0012-1606
keyword: apoptosis
keyword: development
keyword: infoeu-reposemanticsarticle
keyword: journal-articles
keyword: neuron
keyword: polarity
keyword: retina
keyword: sdvbddlife-sciences-q-biodevelopment-biology
issued: 2026-05-11T15:35:20.580496
modified: 2026-05-11T15:35:20.580501
language: en
contact point: Organization
  fn: CCSD

test_moissonnage_selune
type: Agent

Two-color in vivo imaging of photoreceptor apoptosis and development in Drosophila
type: Distribution
format: HTML
access URL: https://ens-lyon.hal.science/ensl-00809185
issued: 2026-05-11T15:35:20.601754
modified: 2026-05-11T15:35:20.567568