11 datasets found

Plasmacytoid dendritic cells (pDC) are able to replicate HIV-1, and the decrease of pDC number in blood is correlated with HIV-1 viremia in patients. During my thesis,...

Viral promoters modulate transcription and hence viral replication. The HIV-1 promoter is polymorph in its transcription factors binding sites. The impact of this...

Nowadays with the newest technologies, the entire genome can be explored to uncover genetic variants which may be linked to diseases. This requires bioinformatics...

The Human immunodeficiency virus type 1 (HIV-1) is a retrovirus with a genome composed of two molecules of single stranded RNA. The reverse transcriptase encoded by...

The 1st strand transfer, a crucial step of reverse transcription involving the HIV-1 nucleocapsid protein (NC), relies on base pairing of the r sequence of strong-stop...

Even though current multitherapies maintain HIV infection under control, they unfortunately do not achieve viral eradication due to the existence of latently infected...

HIV-1 Vif and Vpr proteins may play a role in viral genetic variability. Indeed, Vpr limits error-induced mutations by the viral reverse transcriptase by recruiting...

Thèse réalisée dans le Laboratoire de BioCristallographie du Dr R. HASER et dans le Laboratoire de Virologie et Pathogenèse Virale du Pr. P. BOULANGER

Usurping the host ubiquitination proteasome system (UPS) to inactivate the undesirable host protein is a common viral strategy. HIV-1 proteins inactivate the...

Stage de DESS. Rapport de stage.

Understanding the function of RNA involved in biological processes requires a thorough knowledge of RNA structure. Traditional chemical and enzymatic reagents and...