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Efficient approach to thapsigargins (guaianolides) and synthesis of red azule...
The [2+2] cycloaddition of dichloroketene and 7-methylcycloheptatriene, followed by ring expansion with diazomethane and dehydrohalogenation, affords -chlorotrienone... -
Multicomponent reaction and applications : synthesis of cyclopent[b]indoles a...
This thesis was split in two parts with the same thematic: multicomponent reactions (MCR). In the first one, we were focused on the development of two novel MCR... -
Development of novel antiparasitic agents : towards the total synthesis of ci...
Tropical diseases caused by protozoan parasites such as Trypanosoma brucei, Plasmodium falciparum and Leishmania donovani, infect billions of people worldwide and kill... -
Palladium: reactivity of allyl dienol carbonates & synthetic approach to (-)-...
Since its introduction by Tsuji et al. in the 60s, the palladium catalyzed allylic alkylation has become a powerful tool for the construction of C-C bonds. For our... -
Study toward the total synthesis of natural tetrahydroisoquinolines : quinoca...
Quinocarcin, tetrazomin and lemonomycin constitute a subfamily belonging to the family of natural trisubstituted tetrahydroisquinolines. These are powerful cytotoxic... -
Application of the olefin metathesis reaction to obtain molecules of biologic...
C-C bond formation constitutes a key research field of organic chemistry. Among all existing techniques, olefinmetathesis turned out to be a revolution, especially...
