15 datasets found

A hierarchical SRM acquisition chain model for improved protein quantification in serum samples. Poster + Poster Flash présenté à la conférence RECOMB-CP 2012

The analysis of Cultural Heritage samples brings information on the understanding of a technique and is essential for conservation and restoration issues. However, as...

This thesis has been prepared at the CEA Léti, Minatec Campus, (Grenoble, France) and the IMS (Bordeaux, France) in the field of information and signal processing of...

Terrestrial organisms are exposed to low doses of ionising radiation from natural or anthropogenic sources. The major effects of the radiations are due to DNA...

Proteomics analysis of pathological brain tissue in Parkinson's disease (PD) is of great importance to understand the molecular aetiology of degeneration and to...

In this thesis, we show the importance of the modeling and the cooperation of metaheuristics for solving real problems in Bioinformatics. Two problems are studied :...

Over decades, the peptide fractions produced during cheese ripening have been more and more deeply described(HPLC, tandem mass spectrometry) even if their precise...

In this manuscript, we describe the development and the optimization of an original strategy for the characterization of protein N-termini and protease cleavage sites....

Nanomaterials raise new questions in environmental and human toxicology and represent a novel interface with specific properties with the biological medium. Several...

The first amino acid incorporated in nascent polypeptide chain is always methionine so called N-terminale methionine. However, in a given proteome, more than fifty...

The chapters IV to VII are written in english. The pdf files contain interactive table of contents. The pdf file called "[...]ForPrint" is made for two-sided printing (with...

To better understand the mechanisms governing cellular traffic, transport process of substrates across the tonoplast, storage of various metabolites and their ultimate...

Recent advances in the study of phenomena leading to cancer show that each tumor has their own pathophysiological characteristics. The contribution of biomarkers to...

The proteomic analysis by mass spectrometry is now an essential method for the characterization of proteins. Thanks to advances in instrumentation and bioinformatics,...

Desiccation tolerance (DT) is defined as the ability to survive in the dry state and resume metabolic activity upon imbibition. Unlike orthodox seeds, that acquire DT...