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New pro-apoptotic targets in acute myeloid leukaemia
Acute Myeloid Leukaemia (AML) is a deadly disease characterized by the clonal expansion and accumulation of hematopoietic stem cells arrested at various stages of... -
Cellular factors controlling mutant huntingtin aggregation
Aggregates deposition in neurons of patients is a generic feature of neurodegenerative diseases like Huntington's disease, Parkinson and Alzheimer's diseases. The... -
Study of pathophysiological mechanisms in a mouse model of Emery-Dreifuss mus...
LMNA gene encodes lamin A/C, ubiquitous proteins of the nuclear envelope. Some mutations of LMNA gene lead to Emery-Dreifuss muscular dystrophy (EDMD) that associates... -
Proteomic remodeling of proteasome in right heart failure.
International audience -
La polyarthrite rhumatoïde et les auto-anticorps anti-protéines citrullinées....
Les activités de recherche présentées dans ce document s'articulent en deux parties distinctes. La première partie concerne des travaux réalisés au sein de l'équipe du... -
Identification of a functional destruction box in the Xenopus laevis aurora-A...
International audience -
Development of lipopeptides for inhibiting 20S proteasomes
Proteasomes are responsible for the cytoplasmic turnover of the vast majority of proteins including regulatory proteins. We have synthesized lipopeptides a new class...
