-
Non-linear mixed effects models contributions to the study of pharmacokinetic...
Non-Linear Mixed Effects Models (NLMEM) play an increasing role in drug development process. This work presents various fields of application for NLMEM and... -
ONCOLOGY NANOMEDICINE: Study of Interactions Between Nanoparticles Activated ...
The understanding of interactions between nanomaterials and biological entities is fundamental to develop nanoproducts in oncology. NBTXR3 (hafnium oxide inert... -
Pharmacokinetic pharmacodynamic modeling and simulation methods applied to ev...
Are Evidence-Based Medicine and its associated search for standardization compatible with the patient intra- and interindividual variability in therapeutic response?... -
Pharmacokinetic/pharmacodynamic assessment of the effects of parenteral admin...
Classical pharmacokinetic/pharmacodynamic studies of antimicrobial agents performed by combining plasma concentrations and minimum inhibitory concentrations (MICs) are... -
Development of mechanistic models and evaluation of parameter uncertainty via...
Angiogenesis, the development of new blood vessels from pre-existing vasculator, plays a crucial role in the growth of malignant tumors and the development of... -
Pharmacokinetics and pharmacodynamic modelling of epinephrine and norepinephr...
The effects of catecholamines are difficult to predict. The between-subject variability observed in clinical setting is multifactorial including constitutional and... -
Physiologically-based kinetic modelling (PBK modelling) : meeting the 3Rs agenda
International audience -
From dose to clinical effect : use of modeling through drug development to pr...
Epidemiological data demonstrate an inverse correlation between HDL-cholesterol (HDL-C) levels and cardiovascular risk. Therefore, drugs as cholesteryl ester transfer...
