-
MODELLING NUCLEOCYTOPLASMIC TRANSPORT WITH APPLICATION TO THE INTRACELLULAR D...
In this thesis, I discuss two main subjects coming from biology and I propose two models that mimic the behaviours of the biological networks studied. The first part... -
A dp53-JNK-dependant feedback amplification loop is essential for the apoptot...
International audience -
Effects of nitrated-polycyclic aromatic hydrocarbons and diesel exhaust parti...
International audience -
Diverse p63 and p73 isoforms regulate D133p53 expression through modulation o...
International audience -
Role of p53 pathway in the response of soft tissue sarcomas to TNF-alpha trea...
Introduction: Although named for its antitumor properties, TNF-a is implicatedin a wide spectrum of diseases including chronic inflammation, autoimmunity andcancer. It... -
P53 inactivation leads to impaired motor synchronization in mice.
We have combined genetic and pharmacological approaches to investigate the behavioural consequences of inactivation of the murine p53 protein. Our behavioural analysis... -
Kaposi's sarcoma herpesvirus lytic replication compromises apoptotic response...
International audience -
What mechanisms can't do: Explanatory frameworks and the function of the p53 ...
International audience -
Expression of matrix-metalloproteinases (MMP-2, -7 and -9), tissue inhibitors...
Endometrial carcinoma is the most common gynaecologic malignancy in industrialized countries. Mechanisms involved in endometrial carcinogenesis are not fully... -
Biological functions of p53 isoforms through evolution: lessons from animal a...
The TP53 tumour-suppressor gene is expressed as several protein isoforms generated by different mechanisms, including use of alternative promoters, splicing sites and... -
Apoptosis and p53 are not involved in the anti-tumor efficacy of (125)I-label...
International audience -
Increased galectin-7 gene expression in lymphoma cells is under the control o...
International audience -
Study of the relationship between EGFR/KRAS mutations and p53/p14arf alterati...
We have studied, in the lung adenocarcinomas bearing EGFR or KRAS mutations, TP53/p14arf status, and in the non-small cell lung cancer the contribution of Neurotensin... -
ING1 and ING2: Multi-Faceted Tumor Suppressor Genes
International audience -
Inverse relationship between TCTP/RhoA and p53 /cyclin A/actin expression in ...
International audience -
The p53 protein and its molecular network: modelling a missing link between D...
International audience -
Growth and cell cycle regulation by isoflavones in human breast carcinoma cells
International audience -
Study of mammary stem and progenitor cells and of their contribution in tumor...
Numerous studies suggested that mammary stem and progenitor cells could be targets of the oncogenic transformation in breast cancer, attracting a particular attention... -
Reaction-diffusion systems for spatio-temporal intracellular protein networks...
International audience -
Drosophila p53 isoforms differentially regulate apoptosis and apoptosis-induc...
Irradiated or injured cells enter apoptosis, and in turn, promote proliferation of surrounding unaffected cells. In Drosophila, apoptotic cells have an active role in...
