-
Effect of two epidermal growth factor receptor (EGFR) targeting drugs, cetuxi...
P-glycoprotein (P-gp) is a membrane transporter and belongs to the ATP-binding cassette (ABC) transporter super family. P-gp decreases oral bioavailability of... -
Design and synthesis of azaheterocycles and steroidal bivalent ligands as pot...
Multi-drug resistance (MDR) is characterized by a simultaneous resistance to a wide range of structurally unrelated chemotherapeutic agents, partly caused by the... -
Reversion of MultiDrugResistance (MDR) phenotype by new steroids derivatives,...
The chemoresistance of cancer is characterized by a pleitropic resistance to multiple drugs. This mechanism is partly caused by the overexpression of “ATP Binding... -
Susceptibility of juvenile and adult blood-brain barrier to endothelin-1: reg...
International audience -
Structural and functional study of efflux pumps involved in drug resistance
Resistance to chemotherapy is partly due to efflux pumps expressed in the plasma membrane which prevents the accumulation of anticancer, antiviral, antifungal and...
