15 datasets found

In Alzheimer's disease, neurons die through a process of programmed cell death, called apoptosis. In vivo studies have shown that this stage of somatic destruction,...

Heart failure (HF) is still the major cause of morbimortality in industrialized countries that justify the research of new treatments. Characterized in part by...

Inhibitors of the mitochondrial respiratory chain bc1 complex are currently used against human and plant pathogens. These drugs bind to Qo and Qi pockets of the...

Mitochondria are organelles present in most eukaryotic cells and specialized in the production of energy via the respiratory chain located in their inner membrane....

In this manuscript, we describe the development and the optimization of an original strategy for the characterization of protein N-termini and protease cleavage sites....

Cardiac postconditioning is paradoxical in rat. Certain authors showed that this animal could be protected by postconditioning whereas others showed that it was...

Coenzyme Q (ubiquinone or Q) is a lipophilic organic molecule composed of a substituted benzoquinone and a polyisoprenyl chain containing 6 units in Saccharomyces...

Gene expression in mitochondria is for the most controlled by nuclear encoded proteins that are from the cytosol into the organelle. Recent genetic and biochemical...

Mitochondrial defects and abnormal glutamatergic transmission (excitotoxicity) are the main mechanisms potentially involved in chronic neurodegenerative disorders,...

The majority of nuclear-encoded organellar proteins contain a cleavable presequence, which is necessary for protein targeting and import into the correct cellular compartment....

The neurotrophin receptor TRKC was initially shown to induce apoptosis in settings of lackof its ligand, NT-3. This cell death was described to be important in the...

The complex genetic system of higher plant mitochondria could not be studied by transgenic approaches because conventional methods do not permit genetic transformation...

For several decades, medicine has noted an increase in proliferative diseases, lipid overload and neurodegenerative diseases. The metabolic diseases are the most...

Acyl-CoA oxidase 1 (ACOX1) is the rate-limiting enzyme of the peroxisomal fatty acid β-oxidation pathway of very-long-chain fatty acid (VLCFAs). In humans, ACOX1...

ATP synthase is an essential protein complex located in the mitochondrial inner membrane, which synthesize ATP by coupling to a rotary proton transport across the...