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Challenging Development of a Humanized Mouse Model for Evaluating the HTLV-1 ...
Human T-cell Leukemia Virus type 1 (HTLV-1) is the etiologic agent of the Adult T-cell Leukemia (ATL), an aggressive lymphoproliferation of activated CD4+ T cells. The... -
HBZ-induced functional deregulation of menin - new insights into the mechanis...
Adult T-cell leukemia (ATL) is an aggressive lymphoproliferative disorder associated with human T-cell leukemia virus type 1 (HTLV-1) infection. Reactivation of... -
Role of the mesenchymal niche in SP phenotype regulation of human hematopoiet...
Hematopoiesis is a finely tuned process to allow its long-term efficiency and its adaptation to various physiological and pathological stresses. Hematopoietic stem... -
the role of insulin-like growth factor (IGF-I) secreted by tumoral microenvir...
The microenvironment, composed of several cellular elements and extracellular matrix, plays an important role in tumor development and metastasis. Thus, the study of... -
Functional study of oncogenic KIT : new strategies for selective oncogenic KI...
When overexpressed or constitutively active by mutation, the tyrosine kinase receptor KIT is involved in some proliferative diseases such as gastro-intestinal stromal...
