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Synthesis and evaluation of original analgesics : PDZ domain protein inhibitors
Protein-protein interactions play a central role in the regulation of biological processes and represent a promissing class of therapeutic targets. It has been... -
Design of artificial protein binders by in silico molecular engineering
Artificial mini-proteins able to target catalytic sites of matrix metalloproteinases (MMPs) were designed using a functional motif grafting approach. The motif... -
Protein-protein interaction network inference using statistical learning
The aim of this thesis is to develop tools for predicting interactions between proteins that can be applied to the human proteins forming a network with the CFTR... -
Comparative study of the integrative processes of the avian and porcine retro...
A critical step for retroviral replication is the stable integration of the provirus genome into the genome of its host; this integration is realized by a viral... -
Synthesis and pharmacological evaluation of new biomimetic peptides and benzo...
ATP-sensitive potassium channels (KATP) play an important role in many cellular processes. The modulation of these channels by activating molecules may constitute very...
