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Identification of low molecular weight nuclear complexes containing integrase...
International audience -
The crystallographic study of the catalytic core domain of the avian rous ass...
During the replicative cycle of retroviruses, the retrotranscribed viral DNA is integrated into the host chromosome by the viral integrase protein (IN). The... -
Comparative study of the integrative processes of the avian and porcine retro...
A critical step for retroviral replication is the stable integration of the provirus genome into the genome of its host; this integration is realized by a viral... -
A cohort study of treatment-experienced HIV-1-infected patients treated with ...
International audience -
Molecular mechanism of HIV-1 integrase inhibition by Raltegravir proposed by ...
The HIV-1 integrase catalyzes the integration of HIV-1 viral DNA (vDNA) into the host cell chromosome in a process, which is essential for viral replication through... -
Dual inhibition of HIV-1 replication by integrase-LEDGF allosteric inhibitors...
International audience -
Functional and structural studies of the protein EED, cellular partner of the...
Thèse réalisée dans le Laboratoire de BioCristallographie du Dr R. HASER et dans le Laboratoire de Virologie et Pathogenèse Virale du Pr. P. BOULANGER -
Diketo acids derivatives as dual inhibitors of human immunodeficiency virus t...
The HIV-1 integrase (IN) and reverse transcriptase (RT) are essential enzymes in the virus cycle. RT is crucial for the retrotranscription of the RNA viral genome,...
