12 datasets found

ATAD3A is part of a novel family of mitochondrial AAA+ ATPase (ATPases Associated to diverse cellular Activities) specific to the multicellular eukaryotes (1). In the...

Increasing evidence suggests a critical implication of membrane-associated protease activities in numerous biological processes. ADAM (A Disintegrin and...

La voie de signalisation Notch est une voie de signalisation conservée et primordiale aussi bien pour le développement des métazoaires que la maintenance de leurs...

If it is now widely accepted that sleep is important for memory consolidation, we do not know the exact role of sleep in this process. The purpose of my thesis project...

In eukaryotes, the transcription cycle is composed of several steps, each of them being strictly controlled by several factors. These factors act mainly through...

Sexual reproduction involves dramatic gamete differentiation and profound parental chromosomes remodelling. At fertilization, these chromosomes need to be rendered...

Alzheimer’s disease (AD) is characterized by the accumulation of amyloid β (Aβ) in the brain. Several lines of evidences point towards a strong link between AD and...

Cognitive capacities used to ensure the exploration and discovery of new ecological niches are at the heart of the process of adaptation and survival of vertebrate and...

How oogenesis is controlled upon nutrient challenge is a key biological question to understand the balance between reproduction and adult fitness. During Drosophila...

Most of the progress in dissecting the Drosophila antimicrobial response over the past decade has centered around intracellular signaling pathways in immune response...

In Drosophila, the signaling pathway mediated by the Toll receptor is critical for the establishment of embryonic dorso-ventral pattern and for innate immune responses...

Here we present a 1H −13 C filtered method for localized spectroscopy for the study of mice brain metabolism and, also for the development of localized HRMAS...