34 datasets found

In this work, two TFIIH-related phenomena were investigated : the influence of specific mutations in TFIIH XPD subunits on the transcriptional response of different...

In eukaryotic cells, the genome is packed into chromatin, a hierarchically organized complex composed of DNA and histone and nonhistone proteins. In this thesis we...

RNA interference (RNAi) is a cellular process known for inhibiting gene expression in a sequence-specific manner. In the fission yeast Schizosaccharomyces pombe, this...

Two key cellular processes, namely transcription and replication, require the opening of the DNA double helix and act differently on the two DNA strands, generating...

Eukaryotic genomes are packed into the confines of the nucleus through a nucleoproteic structure called chromatin. Chromatin is a dynamic structure that can respond to...

The ultrastructure of HT29 cells (human epithelial adenocarcinoma cell line) was studied by CEMOVIS (Cryo-Electron Microscopy of Vitreous Sections) with a special...

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Polycomb group (PcG) and trithorax group (trxG) proteins are well known for their role in the maintenance of silent and active expression states of homeotic genes....

FACT is a vital protein which has multiple roles including one in transcription and repair of damaged DNA. However, how FACT assists repair and transcription remains...

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In this work we have studied the mechanisms of regulation of expression of androgen receptor (AR) target genes. We have used an immortalized non-tumorigenic prostate...

Even though current multitherapies maintain HIV infection under control, they unfortunately do not achieve viral eradication due to the existence of latently infected...

In cancer cells, the organization of DNA in chromatin is frequently affected. Thus, it is crucial to understand how factors involved in chromatin organization...

Epigenetics is defined as the study of heritable changes in gene expression that are not accompanied by changes in the DNA sequence. Epigenetic mechanisms include...

DOI:10.1073 pnas.0405316102

Proteins bearing a SET domain have been shown to methylate lysine residues in histones and contribute to chromatin architecture. Methylation of histone H3 at lysine 9...

In eukaryotes, the transcription cycle is composed of several steps, each of them being strictly controlled by several factors. These factors act mainly through...

Proper packaging of eukaryotic genomic DNA into chromatin is important for proper DNA compaction and gene expression regulation. The nucleosome core particle comprises...

The Herpes Simplex type 1 (HSV-1) virus possesses a bimodal mode of infection. It can either replicates in an active way during the lytic cycle, or it can infect...

Predicted climate changes and particularly drought represent a major threat to forest health. Therefore, understanding mechanisms that control trees response to...