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Opposite regulation of the mitochondrial apoptotic pathway by C2-ceramide and...
International audience -
Upstream control of apoptosis by caspase-2 in serum-deprived primary neurons.
During development as well as in pathological situations, neurons that fail to find appropriate targets or neurotrophic factors undergo cell death. Using primary... -
Cell permeable BH3-peptides overcome the cytoprotective effect of Bcl-2 and B...
Peptides corresponding to the BH3 domains of Bax (BaxBH3) or Bcl-2 (Bcl2BH3) are potent inducers of apoptosis when fused to the Atennapedia plasma membrane... -
Le récepteur à dépendance TRKC : mécanismes moléculaires et implications dans...
The neurotrophin receptor TRKC was initially shown to induce apoptosis in settings of lackof its ligand, NT-3. This cell death was described to be important in the... -
Mitochondrial permeability transition as a novel principle of hepatorenal tox...
Atractyloside (Atr) binds to the adenine nucleotide translocator (ANT) and inhibits ANT-mediated ATP/ADP exchange on the inner mitochondrial membrane. In addition, Atr... -
Prolonged, but not acute, glutathione depletion promotes Fas-mediated mitocho...
Glutathione depletion either decreased or increased death-receptor-mediated apoptosis in previous studies. Comparison of the durations of glutathione depletion before...
