32 datasets found

Innate immune response which is characterized by antiviral cytokines such as interferon-alpha (IFN-, is essential during viral infections. Plasmacytoid dendritic...

- Résumé en anglais : Our team is working on the mechanisms of apoptosis induced by nutlin-3, a small molecule which binds to MDM2 and activates p53, in different...

Control of EGFR-L858R oncogenic signaling pathway by the p14ARF tumor suppressor in lung adenocarcinoma. The EGF receptor (EGFR) is a strong oncogene involved in lung...

Colorectal cancer (CRC) is the second most common cause for cancer-related deaths in Europe and in the USA. Because of the limited efficacy and considerable toxicity...

Chikungunya is an Alphavirus transmitted by mosquitoes (Aedes) and which causes fever, rash, myalgia and arthralgia. The disease (CHIKVD) is transient but severe forms...

Two key enzymatic systems in the inflammation process revealed being implicated <br />in many cancers (colon, pancreas, breast, lung) and more particularly in...

International audience

Dependence receptors are a new class of pro-apoptotic receptor able to induce a survival signal in presence of their ligand and, on the opposite site to induce...

Telomerase is a ribonucleoprotein consisting of an RNA component (hTR) that serves as atemplate for the addition of telomeric sequences at the ends of chromosomes and...

Introduction: Although named for its antitumor properties, TNF-a is implicatedin a wide spectrum of diseases including chronic inflammation, autoimmunity andcancer. It...

The control of the apoptosis is one of the new modern key to fight against the cancer. The apoptosis is the self destruction of cells, part of the homeostasis, which...

Acute Myeloid Leukaemia (AML) is a deadly disease characterized by the clonal expansion and accumulation of hematopoietic stem cells arrested at various stages of...

Endometrial carcinoma is the most common gynaecologic malignancy in industrialized countries. Mechanisms involved in endometrial carcinogenesis are not fully...

Glaucoma is the first cause of irreversible blindness in the world. Primary open-angle glaucoma (POAG) mostly combines retinal neuropathy with abnormal elevation of...

Plasmodium species use programmed cell death for the survival of their offspring as some prokaryotic parasites. This study was designed to - assess the gametocytes...

Maternal obesity is associated with a wide spectrum of delivery disorders, such as delayed or post-term delivery, that might be explained partly by the increase in...

Chronic inflammatory diseases are the leading cause of death worldwide with a significant proportion of heart disease and other lipid-inflammatory disorders such as...

Human T lymphotropic virus type 1 (HTLV-1) is the etiological agent of adult T-cell leukemia/lymphoma (ATLL) that develops after several decades and for which there is...

Despite the complexity of the transformation process, several model systems have been developed in which normal cells are transformed in a step-wise manner by...

CD20 is a validated target for the immunotherapy of B lymphoid neoplasms, including ChronicLymphocytic Leukemia (CLL). We compared the activities of rituximab and...